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You are using Science Of Synthesis as a Guest.
Please login or sign up for a free trial to access the full content. Variation 2: Alkylamination under High Pressure

DOI: 10.1055/sos-SD-015-00002

Spitzner, D.Science of Synthesis, (200515175.

4-(Alkylamino)- or 4-(dialkylamino)pyridines, e.g. 738, are synthesized from 4-chloropyridine (737) in high yield by high-pressure-promoted nucleophilic aromatic substitution with primary and secondary amines (Scheme 244).[‌939‌]

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