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15.1.1.4.4.2.4.1 Variation 1: Decarboxylation–Substitution Reactions

DOI: 10.1055/sos-SD-015-00002

Spitzner, D.Science of Synthesis, (200515194.

Pyridine-2-carboxylic acid 1-oxides, e.g. 821, decarboxylate in a mixture of triethylamine and acetic anhydride in acetonitrile to give a carbene intermediate which reacts with acetonitrile to form a 2-(acetylamino)pyridine; the latter is hydrolyzed to give the corresponding pyridin-2-amine, e.g. 822 (besides some pyridin-2-ol 823) (Scheme 272).[‌1056‌]

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