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15.1.2.3.1.2.1.1 Method 1: Decarboxylation and Deacylation

DOI: 10.1055/sos-SD-015-00002

Spitzner, D.Science of Synthesis, (200515212.

Some pyridinecarboxylic acid 1-oxides can be decarboxylated upon heating.[‌1160‌,‌1161‌] In the case of pyridine-2,3-dicarboxylic acid 1-oxide (905), the carboxylic acid group at C2 is lost preferentially to give pyridine-3-carboxylic acid 1-oxide (906). Acid 906 is also obtained from 2-acetylpyridine-3-carboxylic acid 1-oxide (907), which undergoes selective deacetyl­ation under basic conditions or with acid (Scheme 303).[‌1026‌,‌1161‌]

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