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DOI: 10.1055/sos-SD-015-01146

Álvarez, M.; Joule, J. A.Science of Synthesis, (200515664.

Most practical ring-closure syntheses of isoquinolines involve addition of a pyridine (or reduced pyridine) ring to a benzene precursor; there are no useful general methods involving the annulation of a benzene ring onto a pyridine.

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