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Please login to access the full content or check if you have access via15.5.1.1.1.1.1.1.1 Variation 1: From 2-Formylbenzylcarbonyl Compounds
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Álvarez, M.; Joule, J. A., Science of Synthesis, (2005) 15, 665.
The interaction between ammonia and a (2-formylphenyl)acetaldehyde 21 leads directly to an isoquinoline 22 with no substituents on the heterocyclic ring (Scheme 9). The dialdehyde precursors 21 can be conveniently obtained via ozonolysis of indenes 20 and the sequence is conveniently carried out without isolation of intermediates.[28] Dihydroxylation using osmium(VIII) oxide and then periodate cleavage can also be used to access the (2-formylphenyl)acetaldehydes 21.[29]
Meeeee 8 Meeeeeeeeeeee eeee (8-Meeeeeeeeeee)eeeeeeeeeeeee Meeeeeee ee Meeeeeeeee ee Meeeeee[88,88]
Me eeeeeeeeeee eeeee ee 8-(8-eeeeeeeeeeee)eeeee-8-eeee eeeeeee, eeeeeee, ee e eeee eeeeeeeeee eee eeeeeeeee eeee eeeeeeeee eeeeeeeee eeeeeeeeeee, eee eee eeee eee eeee eeeeeee 8-eeeeeeeeeeee eeeeeee 88, eee eeeeee 8-eeeeeeeeeee eeeeeeeeeeeee 88. Meee eeeeee eeeeeee ee eee eeeee-eeeeee eeeeeeeee ee (eeeeeee)eeeeeeeeeeeeeeeee 88 eee eee eeeeeeeee ee eee 8-eeeeeeeeeeee eeeeeee 88 (Meeeee 88).[88]
Meeeee 88 Meeeeeeeeeeee eeee 8-Meeeeeeeeeee Meeeeee Meeeeee eeee (Meeeeee)eeeeeeeeeeeeeeeee[88]
Meeeeeeeeeee Meeeeeeee
8-Meeeeeeeeeeeeeee (88, M8 = 8-M); Meeeeee Meeeeeeee:[88]
M8 eee eeeeee eeee e eeee ee 8-eeee-8M-eeeeee (88, M8 = 8-M; 88 ee, 8.88 eeee) ee eee MM8Me8 (8 eM) ee −88°M eeeee eeeeee eee eeeeeee. Meeeee M8 eee eeeeeee ee eeeeeee eeee M8, eee eeee eeeeeee ee ee, eeee MeMMM8 eee MMM (8.8 eM·eeee−8 eeeeee) eeeee. Mee eeeeeeeee eeeee eee eeeeee eee eeeee 88 e ee ee, ee MM8MM eee eeeee eee eee eeeeeeeee eeeee eeee eee e eeeeeee 88 e ee ee. Mee eeeeeeeee eeeeeee eee eeeeee eeee M8M eee eeeeeeeee eeee MM8Me8, eee eeeeeeee eeee eeeee, eeeeeeeeee, eee eee eeeeeee eeeeeeee ee eeeeeeeeeeeeee (eeeeeee, MM8Me8/eeeeeee 8:8); eeeee: 88 ee (88%); ee 88–88°M (eee).
8-(8-Meeeeeeeeeeee)eeeeeeeeeeee (88, M8 = 8-MeMM8M8); Meeeeee Meeeeeeee:[88]
Meeeeee[8.8.8]eeee-8,8,8-eeeee-8-ee 8-eeeeeeeeeeeeeee (ee. 8.8–8.8 e) eee eeeeeeeee ee MMM[88] ee eeee 8-(8-eeeeeeeeeeee)-8-(8-eeeeeeeeeeeee)eeeee-8-eee (88, M8 = 8-MeMM8M8) ee eeee eeeee. Meee eeeeeeee eee eeeeeee eeee ee MM8MM ee MeMM ee ee ee eeee eee eeeeeee; eeeee: 88%; ee 88–888°M.
References
| [28] | Meeeee, M. M.; Meeeeee, M. M., M. Mee. Meee., (8888) 88, 8888. |
| [29] | Meee, M. M.; MeMeee, M., M. Mee. Meee., (8888) 88, 8888. |
| [30] | Meeeeee, M.; Meee-Meeeeeeee, M.; Meeee, M., Meeeeeeeeee Meee., (8888) 88, 8888. |
| [31] | Meeee, M. M. M., Meeeeeeee Meeeeee ee Meeeeee Meeeeeeee, Meeeeeee: Mee Meee, (8888). |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) M 8e, 888.
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