0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via Variation 7: From 2,2-Dialkoxy-N-(1-arylalkyl)-N-(benzylsulfonyl)ethylamines

DOI: 10.1055/sos-SD-015-01146

Álvarez, M.; Joule, J. A.Science of Synthesis, (200515714.

When, instead of a tosyl group on the nitrogen (Section, a benzylsulfonyl group is employed, the ring closure of 196 proceeds well to give 2-(benzylsulfonyl)-1,2-dihydroisoquinoline 197, and additionally, final treatment with Raney nickel leads to removal of the N-substituent and aromatization giving 198 (Scheme 90).[‌171‌]

Meeeee 88 Meeeeeeeeeeee eeee 8,8-Meeeeeee-M-(8-eeeeeeeee)-M-(eeeeeeeeeeeeee)eeeeeeeeeee[‌888‌]

Meeeeeeeeeee Meeeeeeee

8,8-Meeeeeeee-8-eeeeeeeeeeeeeeeeee [888, M8=8,8-(MMe)8; M8=Me]; Meeeeee Meeeeeeee:[‌888‌]

M-(Meeeeeeeeeeeee)-M-[8-(8,8-eeeeeeeeeeeeeee)eeeee]-8,8-eeeeeeeeeeeeeeeeeee [888, M8=8,8-(MMe)8; M8=Me; 888ee, 8.8eeee], eeeeeeee ee e Meeeeeeee eeeeeeee, eee eeeeeeeee ee eeeeeee (88eM), ee 8M MMe (8 eeeee) eee eeee eeeee eee eee eeeeeeee eeeeeeee eee 88eee. Meeeeeeeeeee eeeeeeeeee eeeeee eee eeeeeeeeeeeeee eeee eee 8-(eeeeeeeeeeeeee)-8,8-eeeeeeeee-8-eeeeee-8,8-eeeeeeeeeeeeeeeeeee [888, M8=8,8-(MMe)8; M8=Me]; eeeee: 88%; ee 888888°M.

Meeeeee eeeeeeee Meeee eeeeee (8e·eee8) ee eee MeMM eee eeeee ee ee eeeeeeeee eeee ee eee eeeeeeeeeeeeeeeeeee 888 [M8=8,8-(MMe)8; M8=Me; 888ee, 8.88eeee] eee eee eeeeeee eeeeeee eeeee eeeee eee 8e ee ee. Mee eeeeeeee eee eeeeeeeee ee eeeeeeeeeee eee eeeeee eeee MeMM (8×8eM), eee eeeeeeee MeMM eeeee eeeeeeee eeeeeee Meeeee eee eeeeeeeeee ee eeee eee eeeeeee; eeeee: 888ee (88%); ee 888888°M.