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Please login to access the full content or check if you have access via15.5.1.1.1.5.1.1.7 Variation 7: From 2,2-Dialkoxy-N-(1-arylalkyl)-N-(benzylsulfonyl)ethylamines
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Álvarez, M.; Joule, J. A., Science of Synthesis, (2005) 15, 714.
When, instead of a tosyl group on the nitrogen (Section 15.5.1.1.1.5.1.1.6), a benzylsulfonyl group is employed, the ring closure of 196 proceeds well to give 2-(benzylsulfonyl)-1,2-dihydroisoquinoline 197, and additionally, final treatment with Raney nickel leads to removal of the N-substituent and aromatization giving 198 (Scheme 90).[171]
Meeeee 88 Meeeeeeeeeeee eeee 8,8-Meeeeeee-M-(8-eeeeeeeee)-M-(eeeeeeeeeeeeee)eeeeeeeeeee[888]
Meeeeeeeeeee Meeeeeeee
8,8-Meeeeeeee-8-eeeeeeeeeeeeeeeeee [888, M8 = 8,8-(MMe)8; M8 = Me]; Meeeeee Meeeeeeee:[888]
M-(Meeeeeeeeeeeee)-M-[8-(8,8-eeeeeeeeeeeeeee)eeeee]-8,8-eeeeeeeeeeeeeeeeeee [888, M8 = 8,8-(MMe)8; M8 = Me; 888 ee, 8.8 eeee], eeeeeeee ee e Meeeeeeee eeeeeeee, eee eeeeeeeee ee eeeeeee (88 eM), ee 8 M MMe (8 eeeee) eee eeee eeeee eee eee eeeeeeee eeeeeeee eee 88 eee. Meeeeeeeeeee eeeeeeeeee eeeeee eee eeeeeeeeeeeeee eeee eee 8-(eeeeeeeeeeeeee)-8,8-eeeeeeeee-8-eeeeee-8,8-eeeeeeeeeeeeeeeeeee [888, M8 = 8,8-(MMe)8; M8 = Me]; eeeee: 88%; ee 888–888°M.
Meeeeee eeeeeeee Meeee eeeeee (8 e·eee−8) ee eee MeMM eee eeeee ee ee eeeeeeeee eeee ee eee eeeeeeeeeeeeeeeeeee 888 [M8 = 8,8-(MMe)8; M8 = Me; 888 ee, 8.88 eeee] eee eee eeeeeee eeeeeee eeeee eeeee eee 8 e ee ee. Mee eeeeeeee eee eeeeeeeee ee eeeeeeeeeee eee eeeeee eeee MeMM (8 × 8 eM), eee eeeeeeee MeMM eeeee eeeeeeee eeeeeee Meeeee eee eeeeeeeeee ee eeee eee eeeeeee; eeeee: 888 ee (88%); ee 888–888°M.
References
| [171] | Meeeee, M. M.; Meeeeee, M. M., Meeeeeeeeee Meee., (8888) 88, 8888. |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) M 8e, 888.
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