You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via15.5.1.1.1.5.1.1.9 Variation 9: From (Benzylamino)acetates
Please login to access the full content or check if you have access via
Álvarez, M.; Joule, J. A., Science of Synthesis, (2005) 15, 715.
Cyclization of (benzylamino)acetates 201 with hot concentrated sulfuric acid affords good to excellent yields of 2,3-dihydroisoquinolin-4(1H)-ones 202 (Scheme 92).[173]
Meeeee 88 8,8-Meeeeeeeeeeeeeeeee-8(8M)-eeee eeee (Meeeeeeeeee)eeeeeeee[888]
Meeeeeeeeeee Meeeeeeee
8-Meeeeee-8,8-eeeeeeeeeeeeeeeeee-8(8M)-eee (888, M8 = M8 = M8 = M8 = M); Meeeeee Meeeeeeee:[888]
Me M8MM8 (88% ee eeeeee, 8.8 eM) eee eeeee eeeeeeeeee eeeee (8-eeeeeeeeeeeeeeeeee)eeeeeee (888, M8 = M8 = M8 = M8 = M; 88 ee, 8.8 eeee) eeee eeeeeeee eeeeeee. Mee eeeeeeeee eeee eee eeee ee 888°M eee 8 e, eeeeee ee ee eee eeeee eeeeee eeee eeeeeeee ee eee-eeee 8 M MeMM (8 M). Mee eeeee eeee eee eeeeeeeee eeee MMMe8. Mee eeeeeeee eeeeeeee eeeeeeee eee eeeeeee; eeeee: 88 ee (88%); ee 888–888°M.
References
| [173] | Meeeee, M.; Mee, M. M.; Meeeeeeee, M.; Meeeee, M., M. Mee. Meee., (8888) 88, 888. |
Return to Top