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Please login or sign up for a free trial to access the full content. Variation 7: From 2-Aryl-N-(thioacyl)ethylamines

DOI: 10.1055/sos-SD-015-01146

Álvarez, M.; Joule, J. A.Science of Synthesis, (200515725.

It is possible to use mercury(II) chloride, in a ratio of 3:1 to an appropriate thioamide 231 for the formation of 3,4-dihydroisoquinolines 232 (Scheme 105).[‌211‌] The value of this route depends on the ease of synthesis of the thioamide starting materials, but these are generally prepared from the corresponding amides, which would be the substrates for normal BischlerNapieralski ring closures.

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