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Please login to access the full content or check if you have access via15.5.1.2.1 Method 1: Dehydrogenation of 1,2,3,4-Tetrahydroisoquinolines
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DOI:
10.1055/sos-SD-015-01146
Álvarez, M.; Joule, J. A., Science of Synthesis, (2005) 15, 731.
Many ring-closing syntheses produce 1,2,3,4-tetrahydroisoquinolines, and where efforts have been made to produce enantiomerically pure, or at least sterically defined, tetrahydro derivatives, there is certainly no intention to aromatize subsequently. However, methods exist for such transformations, and so such syntheses could, if so desired, produce isoquinolines on the application of one of the available methods for dehydrogenation.
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