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DOI:
10.1055/sos-SD-015-01146
Álvarez, M.; Joule, J. A., Science of Synthesis, (2005) 15, 735.
Important and widely used ring-closing syntheses produce 3,4-dihydroisoquinolines, in some cases enantiomerically pure, or at least sterically defined, where clearly there is no intention to subsequently aromatize. However, methods exist for such transformations, and so such syntheses, could, if so desired, produce isoquinolines on the application of one the available methods for dehydrogenation. Some dehydrogenations of 1,2,3,4-tetrahydroisoquinolines have as an intermediate a 3,4-dihydroisoquinoline (see Section 15.5.1.1.1.5.2.1).
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