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15.6.1.1.1.1.4.2.5.1 Variation 1: From 2-Halobenzamides

DOI: 10.1055/sos-SD-015-01386

Álvarez, M.; Joule, J. A.Science of Synthesis, (200515853.

Replacement of a halogen ortho to the carboxamide of a benzamide by an acylalkyl substituent produces an intermediate 42 which easily ring closes with loss of water to give an isoquinolin-1(2H)-one 43 (Scheme 27). The displacement is achieved by the relatively unused SRN1 (Ar) reaction in which an enolate anion displaces the halide with UV irradiation.[‌42‌]

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