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15.6.2.1.1.2.1.1 Method 1: From Phenylacetyl Chlorides and Imidoyl Chlorides

DOI: 10.1055/sos-SD-015-01386

Álvarez, M.; Joule, J. A.Science of Synthesis, (200515890.

Internal α-amidoalkylation can be used for the preparation of 1-phenylisoquinolin-3-ols.[‌131‌] The adducts of arylacetyl chlorides and imidoyl chlorides have been used for the preparation of several isoquinolin-3(2H)-ones 138 (Scheme 88).

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