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16.10.4.1.3.3 Method 3: By Hetero Nucleophiles via Nucleophilic Substitution

DOI: 10.1055/sos-SD-016-00385

Haider, N.; Holzer, W.Science of Synthesis, (200416350.

Substitution of heteroatoms in the 1(4)-position by hetero nucleophiles is one of the most frequently applied reactions in phthalazine chemistry and permits the introduction of halogen, chalcogen, and nitrogen substituents. Such reactions have been extensively reviewed in HoubenWeyl, Vol.E 9a, pp768778.


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