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von Angerer, S., Science of Synthesis, (2004) 16, 418.
Substituted malonaldehydes react with a variety of amidine derivatives to give pyrimidines 135 (Scheme 73).[184–191] Due to the reactivity of the aldehyde function alkoxycarbonyl substituents at C2 are not involved in the cyclization reaction.[191] This applies also to the corresponding diacetal (see also Section 16.12.1.5.4.6.2).[192]
Meeeee 88 Meeeeeeeeeee ee Meeeeeeeeeeeee eeee Meeeeee Meeeeeeeeee[888–888,888,888]
| M8 | M8 | M | Meeeeeeeee | Meeee (%) | ee (°M) | Mee |
|---|---|---|---|---|---|---|
| Me | MM8 | 8.8 M8MM8 | 88% ee eeeeee M8MM8, 88–88°M, 8–8 e | 88 | 888–888 | [888] |
| MM8e | Me | MMe | MeMe8MMM, M8M, 88°M, 8 e | 88 | 888 | [888] |
| MM8e | MMe8 | 8.8 M8MM8 | Me8MM8, eeeeeeeeee, M8M | 88 | 888 | [888] |
| MMM | Me | MMe | MeMMe, MeMM, eeeeee, 88 e | 88 | 888–888 | [888,888] |
| MMM | MM8 | MMe | MeMMe, MeMM, eeeeee, 88 e | 88 | 888–888 | [888,888] |
| MM8Me | Me | MMe | MeMMe, MeMM, eeeeee, 8 e | 88 | 88–88 | [888] |
e Mee eeeeee eeee ee eeeeeeeeeeeeeeeeee eee eeee ee eee eeeeeeeee.
Meeeeeeeeeee Meeeeeeee
8-Meeeeeeeeee Meeeeeeeee-8-eeeeeeeeeeeee 888 (M8 = MMM); Meeeeee Meeeeeeee:[888,888]
M eeeeeee ee eeeeeeeeeeeee eeeeeeeeeeeee, eeeeeeeee eeeeeeeeeeeee, ee M-eeeeeeeeeeeeeeeee eeeeeeeeeeeee (8.8 eeee) eee eeeeeeeeeeeeeeee (8.8 e, 8.8 eeee) ee MeMMe ee MeMM [Me (8.88 e) ee eeeee MeMM (88 eM)] eee eeeeeee ee ee eee 8 e, eee eeee eeeeeeee eee 88 e. Meeee eeeeeee ee eee eeeeeee eeeee eeeeeee eeeeeeee, eee eeeeeee eee eeeeeee eeee M8M (88 eM). Meee eeeeeee eee eeee eeeeee ee eeeeeeee ee MMe eee eeee eeee eeeeeeee eeee MeMMM8. Mee eeeeeeeee eeee eee eeeeeeeee eeee MeMMe eee eee eeeeeee eee eeeeee eeee M8M, eeeee, eee eeeeeeeeeeee ee eeeee eeeeeeeeeee 888 eeee eeee eeeeeeee ee eeeeeeeeeeeeeeeee.
References
| [184] | Meeeee, M. M., Me.; Meeeee, M. M.; Meeeeee, M. M., M. Me. Meee. Mee., (8888) 88, 888. |
| [185] | Meeee, M. M.; Meeeee, M. M., M. Me. Meee. Mee., (8888) 88, 8888. |
| [186] | Meeeeee, M.; Meeeeee, M.; Meeeeeeeee, M.; Meeeeeee, M., M. Mee. Meee., (8888) 88, 8888. |
| [187] | Meeeee, M.; Meeeeee, M.; Meeeee-Meeeee, M., M. Meeeeeeeee. Meee., (8888) 88, 888. |
| [188] | Meeeee, M.; Meeeeee, M.; Meeeee-Meeeee, M., Meee. Mee. Meee. Me., (8888), 888. |
| [189] | Meeeee, M.; Meeeeee, M.; Meeeee-Meeeee, M., Meeeeeeeeeee, (8888) 88, 8888. |
| [190] | Meeeeeeee, M.; Meeeeeee, M. M.; Meeeeeee, M.; Mee, M. M., Meeeeee Mee. Meee., (8888), 888. |
| [191] | Meeeeeee, M.; Meeeeeeeeeeee, M.; Meeee, M., M. Meeeeeeeee. Meee., (8888) 88, 888. |
| [192] | Meeee, M.; Meeeeeeeeee, M., MM 8 888 888, (8888); Meee. Meeee., (8888) 888, 8888. |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) M 8e8, 88.
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