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Please login or sign up for a free trial to access the full content. Method 1: Of Pyrimidinethiols with Raney Nickel

DOI: 10.1055/sos-SD-016-00463

von Angerer, S.Science of Synthesis, (200416542.

Pyrimidine-2-thiones and 2-(methylsulfanyl)pyrimidines are readily desulfurized to 2-unsubstituted pyrimidines 456 by heating them with Raney nickel (Scheme 252).[‌145‌,‌543‌,‌623‌,‌632‌,‌673‌,‌676‌,‌678‌,‌766‌‌768‌] Oxidation of pyrimidin-2-thiones with hydrogen peroxide,[‌769‌] peracetic acid,[‌770‌] or ozone[‌771‌] can also be utilized for the removal of sulfur, but the reaction is less reliable than the reduction.

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