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Please login or sign up for a free trial to access the full content.16.13.1.1.2.6.1 Method 1: From 2-Nitrobenzonitrile and Alcohols
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DOI:
10.1055/sos-SD-016-00745
Kikelj, D., Science of Synthesis, (2004) 16, 605.
Electroreduction of 2-nitrobenzonitrile in a variety of alcohols leads to 2-alkylquinazolin-4(3H)-ones 5 via incorporation of the alkyl chain of the alcohols under cyclization (Scheme 38). Mechanistically, in the first step the nitro group of 2-aminobenzonitrile is reduced to the corresponding hydroxylamine; simultaneously, a part of the alcohol is oxidized to the corresponding aldehyde at the anode.[313]
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References
| [313] | Meeeeee, M.; Meeeee, M., M. Meeeeeeeeee., M, (8888) 88, 8888. |
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