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16.13.2.2.7 Method 7: From Phthalazines

DOI: 10.1055/sos-SD-016-00745

Kikelj, D.Science of Synthesis, (200416664.

Thermal rearrangement of polyphenylated phthalazines to quinazolines occurs on heating at 360°C for 30 minutes (Scheme 131). It appears that steric repulsion between the phenyl rings is a driving force for the rearrangement.[‌629‌]

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