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16.17.1.4.1 Method 1: From 4(5)-Aminoimidazole-5(4)-carboxamides

DOI: 10.1055/sos-SD-016-01192

Seela, F.; Ramzaeva, N.; Rosemeyer, H.Science of Synthesis, (200416983.

4(5)-Aminoimidazole-5(4)-carboxamides are the most common imidazole-derived precursors for oxopurines, such as hypoxanthine, xanthine, guanine, and isoguanine, using various condensation reagents. The first purine synthesized by this route was reported by Sarasin and Wegmann in 1924.[‌239‌] 7-Methylxanthine was obtained from 4-amino-1-methyl-1H-imidazole-5-carboxamide and diethyl carbonate.[‌239‌]

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References


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