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16.17.3.3.1 Method 1: By Deuteration and Tritiation

DOI: 10.1055/sos-SD-016-01192

Seela, F.; Ramzaeva, N.; Rosemeyer, H.Science of Synthesis, (2004161003.

The most widely studied exchange reaction of a hydrogen bound to a carbon in a purine ring for deuterium or tritium involves the C8 proton. Reactions with the C6 and C2 protons are generally negligible. For the exchange reactions, deuterium oxide or tritium oxide is used, e.g. formation of [8-2H]purine (111) and [8-3H]purine (112) (Scheme 69).[‌316‌]

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