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16.17.3.4.1.1.1 Variation 1: By Exchange of Chlorine for Fluorine

DOI: 10.1055/sos-SD-016-01192

Seela, F.; Ramzaeva, N.; Rosemeyer, H.Science of Synthesis, (2004161039.

Several 7- or 9-alkylated 2-, 6-, and 8-fluoropurines have been prepared by heating the corresponding chloropurines with silver(I) fluoride in a high boiling solvent,[‌466‌,‌467‌] e.g. the formation of 6-fluoro-9-methyl-9H-purine (177) (Scheme 100).[‌467‌] Attempts to convert 2-chloropurine, 8-chloropurine, and 6-chloropurin-2-amine directly into the corresponding fluoropurine derivatives are unsuccessful; the starting material is recovered in each case.[‌467‌] The use of potassium fluoride in dimethylformamide for the chlorofluoro exchange of 6-chloropurine only results in decomposition and polymeric products.[‌467‌]

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8-Meeeee-8-eeeeee-8M-eeeeee (888); Meeeeee Meeeeeeee:[‌888‌]

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8-Meeeee-8-[8-eeeeeee-8-(eeeeeeeeeeeee)eeeee]-8M-eeeee-8-eeeee (888):[‌888‌]

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References


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