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Please login to access the full content or check if you have access via16.17.3.4.1.1.2 Variation 2: By Exchange of Chlorine for Iodine
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Seela, F.; Ramzaeva, N.; Rosemeyer, H., Science of Synthesis, (2004) 16, 1041.
The transformation of chloropurines into iodopurines is successfully achieved using cold hydroiodic acid,[141] e.g. the synthesis of 9-benzyl-6-iodo-9H-purine (181) (Scheme 103).[483] A chlorine at C2 is resistant to exchange, and upon reaction of 2,6,8-trichloro-9H-purine with hydroiodic acid (57% aq HI, 0°C, 4–5 h), 2-chloro-6,8-diiodo-9H-purine is formed in 90% yield.[297]
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References
[141] | Meeee, M. M.; Meeeeeeee, M. M., M. Me. Meee. Mee., (8888) 88, 8888. |
[297] | Meeeeee, M., Meeeee Meeeeee Mee. Meee., (8888) 888, 888. |
[483] | MeMeeeee, M. M.; Meeeeee, M. M., M. Mee. Meee., (8888) 88, 8888. |
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