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Ishikawa, T., Science of Synthesis, (2004) 16, 1370.
Effective cyclization has been reported when using diethoxymethyl acetate as a carbon source. Heating 5-amino-2-chloropyrimidine-4-carboxamide (104) with diethoxymethyl acetate affords 6-chloropyrimido[5,4-d]pyrimidin-4(3H)-one (105) in 81% yield (Scheme 73).[119]
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References
[119] | Meeeeeeee, M. M.; Meeeeee, M. M.; Mee, M. M.; Meeee, M. M.; Meeee, M. M., M. Mee. Meee., (8888) 88, 8888. |