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Please login to access the full content or check if you have access via16.22.4.1.1.1.2.2 Variation 2: From 2,6-Disubstituted 4-Aminopyrimidine-5-carboxamides
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Ishikawa, T., Science of Synthesis, (2004) 16, 1371.
4-Aminopyrimidine-5-carboxamides 108, obtained by hydrolysis of the corresponding carbonitriles,[104] are key structures in the synthesis of pyrimidopyrimidines. Heating them with triethyl orthoformate in the presence of an acid anhydride affords pyrimido[4,5-d]pyrimidin-4-ol systems 109, in which the acid anhydride is used to remove the ethanol formed during the reaction (Scheme 76).[102,104,105,107,130–132]
Meeeee 88 Meeeeeee[8,8-e]eeeeeeeee-8-eee eeee 8-Meeeeeeeeeeeeee-8-eeeeeeeeeeee[888,888,888,888,888–888]
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Meeeeeeeeeee Meeeeeeee
Meeeeeee[8,8-e]eeeeeeeee-8-ee (888, M8 = M8 = M8 = M); Meeeeee Meeeeeeee:[888]
M eeeeeee ee 8-eeeeeeeeeeeeeee-8-eeeeeeeeeee (888, M8 = M8 = M; 8.8 e, 8.8 eeee), Me8M (8 eM), eee MM(MMe)8 (8 eM) eee eeeeeeee eee 8e eee eeee eee eeeeee eeeeeeee eeee eeeeeeeeee ee 88°M eeeee eeeeeee eeeeeeee. Meeee eeeeeeee ee eee-eeeeee eeeeeee (88 eM), eee eeeeeeeee eeeee eee eeeeeeeee ee eeeeeeeeee eee eeeeeeeeeeeeee (M8M); eeeee: 8.88 e (88%); ee 888–888°M (eee).
References
[102] | Meeeeee, M. M., M. Mee. Meee., (8888) 88, 8888. |
[104] | Meeeeeeeee, M. M.; Meeee, M., M. Mee. Mee. Mee., Meee. M, (8888) 88, 88; Meee. Meeee., (8888) 88, 88888. |
[105] | Meeeeeee, M.; Meeee, M. M.; Meeeeee, M. M.; Meeeeeeeee, M. M.; Meeeeee, M. M.; Meeeee, M. M.; Meeeeeeee, M., M. Mee. Meee., (8888) 88, 888. |
[107] | Meeee, M. M.; Meeee, M. M.; Meeee, M. M.; Meeeee, M.; Möeee, M. M., M. Me. Meee. Mee., (8888) 88, 8888. |
[130] | Meeeeeee, M. Me.; Meeeee, M. M.; Meeeeeee, M. M.; Meeeeee, M. M.; Meeeeeeee, M. M., Meee. Meeeeeeeeee. Meeeee., (8888), 888; Meee. Meeee., (8888) 88, 888888. |
[131] | Meeee, M. M.; Meeeee, M. M.; Meee, M. M., M. Meeeeeeeee. Meee., (8888) 88, 8888. |
[132] | Meeeeeeee, M.; Meeee, M.; Meeeeee, M.; Meeeee, M.; Meeeee, M., Meeee. Meee. Mee. Meee., (8888) 88, 888; Meee. Meeee., (8888) 88, 88888. |
[133] | Meeeeee, M.; Meeeeeeeeeee, M.; Meeeeee, M., Meeee. Meee., (8888) 88, 88. |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) M 8e, 888.