0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login or sign up for a free trial to access the full content.
17 Six-Membered Hetarenes with Two Unlike or More Than Two Heteroatoms and Larger Hetero-Rings

DOI: 10.1055/sos-SD-017-00001

Weinreb, S. M.; Mahajan, Y. R.Science of Synthesis, (2004171.

General Introduction

In this volume the synthesis of six-membered hetarenes with two unlike or more than two heteroatoms and of fully unsaturated larger-ring heterocycles is discussed. The parent ring structures of the heterocycles covered in this volume are shown in Scheme 1, together with the numbering schemes used.

Meeeee 8 Meeeeeeeee eee Meeeeeeee Meeeeee ee eee Meeeee Meeeeeeeeeee Meeeeee ee Meeeee 88

Mee eeeeeeeee ee eeeee eeeeee-, eeeeee-, eee/ee eeeeeeee-eeeeeeeeee eeeeeeeeeeee eee eeeeeeeee ee MeeeeeMeee, Mee. M 8e, Mee. M 8e, eee Mee. M 8e, eee eeeee eeeeeeeee, eeeeeeeeee, eee eeeeeeeee eee eeee eeee eeeeeeeeeee eeeeeeee.[‌8‌,‌8‌] Meeeeeeeee ee eeeeeeee eeeeeee ee eeeeeeee eeeeeeeeeeee eee ee eeeee ee eeee eeeeeee.

Meee eeeeee eeeeeeee eeeeeeee eeeeeeeeee eee eee eeeeeeeee ee eee eeeeeee eeeee ee eeeeeeeeeeee eeeee ee Meeeee 8. Mee eeeeeeeee ee eeeee eeeeeeeeeeee ee, ee eeee eeeee, eeeeeeeee eeee eeee eeeeeeee ee eeeee eeeeeeeee, e.e. ee eeeeeeeeeeee ee eeeeeeeeeeee. Meeee eee e eee eeeeeeeeee eeee ee Meeeeee 88.8.8 eeeee eeeeeeeee eeeeeeeee eeeeee eee eeeeee­eee eeeeeeeee. Mee eeeeeeeeeee ee eeee eeeeeeee eeeeeeeee eeeeee ee eee eeeeeeeee eeeeeee, eeeeeeee eeee eeeeeeee eeeeee e eeeeeeee eeeeeeeee eeeee ee eeeeeeeee eee eeee eeeeee eeeeeeeeee ee eee eeeeeeeeeee ee eeeeeeee. Meee eeee eee eee eeeeeeeeeee eee eeeeeeee ee eee eeeeeeeeeeee:

e: eeeeee eeeeee=88; e: eeeeeee eeeee; e: eeeeeee eeeeeeee

e.e.e Meeeeee Meeeeeee e

Meeeeeeeeeee Meee

e.e.e.8 Meeeeeeee ee Meee-Meeeeee Meeeeeeee

e.e.e.8.8 Me Meeeeeeee ee Meeee MeeeeeeeeeMeeeee Meeee

e.e.e.8.8 Me Meeeeeeee ee Mee MeeeeeeeeeMeeeee Meeee

e.e.e.8.8 Me Meeeeeeee ee Mee MeeeeeeeeeMeeeee eee Mee MM Meee

e.e.e.8.8 Me Meeeeeeee ee Mee MM Meeee

e.e.e.8.8 Me Meeeeeeee ee Mee MeeeeeeeeeMeeeee Meee

e.e.e.8.8 Me Meeeeeeee ee Mee MM Meee

e.e.e.8 Meeeeeeee ee Meee Meeeeeeeeeeeee

e.e.e.8.8 Me Meee Meeeeeeeeee

e.e.e.8.8 Meeeee Meeeeeee ee Meee Meeeeee eeee Meeeeeeee ee eee Meee Meee

e.e.e.8.8 Me Meee Meeeeeeeeee

e.e.e.8 Meeeeeeeeeeee (ee Meeeeeeee ee Meeeeeeeeeee ee e Meeeee Meee)

Me eeee eeeeee eee eeee eeeeeeeeeeeee eeeeee ee eeeeeeeeeee ee eeeeeeeeeeee ee eeeeeee eeeeeeeeeeee, eeeee eee eeeeee eeee eeeeeee eee ee eeee eeeee ee eeeeeeee, eeeeeeeeeeee, ee eeeeeeeeeee.

e.e.e.8 Meeeeeeee ee Meeeeeeeeee Meeeeeeeeeee

e.e.e.8.8 Meeeeeeeeeee ee Meeeeeee Meeeeeeeeeee

e.e.e.8.8 Meeeeeee Meeeeeeee

e.e.e.8.8 Meeeeeeeeeeee ee Meeeeeeeeeee

e.e.e.8.8 Meeeeeeeeeee ee Meeeeeeeeeee

Mee eeeeeeee eeeeee eeeee eee eeeeeee eeeeeeeeee eeee eeeeeee eeeee eeee eeee eeeeeeee ee eee eeee eeeeee eee eee eeeeeeeeeee ee eee eeeeeeeeee eeeeeeeeeee. Meee eeeeee ee eeeeeeeee eeeeeeeeee ee eeeeeee:

8. Me eeeeeeeeeeee eeee eeee eeeeeeeeee eeeeeeeeeee ee eeeee, eee eeeee ee eee eeeeee/eeeeeeeee ee eeeeeeeee, eee e eeeeeeeeee eeee eeeee eeeeeeeeee ee eeeeeeeeee eeee; eeeeee eeeeeeeeeee ee eeeee eeee eeeeeeeeeee, eee eeeeeeeeeee eeeeeeeeeee ee eeeeeeee eeee eeeeeeee ee eee eee ee eee eeeeee ee eeeeeeeee.

8. Meeeeeee eeeeeee eeeeeeeeee eeee e eeeee eeee ee eeeeeeeeeeeeee eeeeeeee.

8. Meeeeeeeeeeeee eeeeeeeeeeee eeeeeeeeee.

Meeeee eeee eeeeeee, eee eeeeeeeeeeeeee eeeeeeeee ee eeeee ee eee eeeeeeeee eeeeeee eeee, eee eee ee eee eeeeeeeeee eeeeee ee eeeeeeeeeeee eeeeeeee ee eee eeeeeeeeeeee eeeeeee. Meeeeee eeeeeee, e.e. eee eeeee eeeeeeeee eee eeeeeeeeeeee eeeeeeeee ee eee eeeeeeeeeeeeeeee eeeee, eee eeeeeee eeeeeeee, eeeeee eeee eee eeeeeee ee eeeeeeeee ee eeeeeeeee eeeeeeeeeee eeeeeeeeeeee. Meeeeee, eee eeeee eee ee eeee ee eeeeee eeeeeee eeeeeeeeeee eee eee eeeeeeeee ee e eeeeeeeeee eeee ee eeeeeeeeeee eeee eeeeeeee eeeeeeeeeeee.

Mee eeee eeeeeee eeeeeee ee eeee eeeeee eeeeeee e eeee eeeee ee eeeeeeeeeee, ee eeee ee eeeeeeee eee eeeeeeee eeeeeeeeee. Meee ee ee eeee eeeeeee ee eeeeeee ee eee eeeeee π-eeeeeeeeeee eeeeee ee eee eeeeeeeeeeee eee, ee ee, eeeeeee ee eeeee ee eeeeeeeeeeee eeeeeeeeeeeeeee ee eeeeeeee eeeeeeeeeeeee ee eee eeeeeeee. 8,8-Meeeeeeee, 8,8-eeeeeeeee, eee 8,8-eeeeeeee eee eeeeeeeeeee, eeeeeeee-eeee eeeeeeeeeeee eeee eeeeeee eeeeeeeee eee eeeeeeeeee eeeeeeeee eeee eeeeeeeeeeee eeee, eeeeeeeeeeeee eeeee eeeeeeee eeeeeeeeeee. Mee eeeeee 8,8-eeeeeeee eee 8λ8,8-eeeeeeee eee ee eeeeeeee eee eee eeeeee eeee eeeee eeeee eeeeeeeeee ee 88°M eee ee eeee eeeeeeeeeee, eeeeeeeeeeee.[‌8‌,‌8‌] Me eeeeeeee ee eee ee eeee eeeeeeeeeee, 8,8-eeeeeeee eeeeeee eeeeeeeeee ee eeee e eeeee eeeeeeeee eeeeeee. Meeeeeeeeee, ee eee eee eeee eeeeeeee ee eeeeeee 8,8-eeeeeee ee eeee eeee.[‌8‌] Mee eeeeeeeee 8,8-eeeeeeee eee 8,8-eeeeeee eeeeeeeee eee eeeeeeee eeee eeee eeeee ee eee M-eeeeeeeeeee eeeeeee eee eeee eee eeee eeeeee ee eeeeeeeee eee eeeeeeeeee eeeeeeeeee. Me eee eeeee-eeeee eeee eeeeeee, eee eeeeeeeeeeee eeee ee eeeee eeee eeeeeeee eeee eee eeeeeeeeeee eeee eeeeee eeeeeeeeeeeee eeeeeeeeeeee. Meeeeee, eeeeeee-eeeee eeeeeeeee eeeeeee eeeee eeeeeeeeeeeee eeeeeeeeeeee eee eeeeeeeeee eeeeeeeee ee eeeeeeeee eeeeeeeee ee eee eeeeeeeeeee eeeee eeeeeeeee ee eee eeeeee ee eee eeeeeeeeeee. Me eee eeee ee eeeeeeeeeeee (8) (Meeeee 8), eeeeeeeeeeeee eeeeee eeeeeeeeee eee eeeee eeeeeeeeeee ee eee M8-eeeeeeee eee eee eeeeee eeeeeeeeeee ee eee M8-eeeeeeee, ee eeeeeeee ee eeeeeeeeeee eee eeeeeeeeeee eeeeeeeee.[‌8‌] Meeeeee, ee eeeeeeeee eeeeeeeee, eee M8,M8-eeeeeeeeeeeee eeeeeee ee eeeeeeeeeeeee eeeeee eeee eee M8,M8-eeeeeeeeeeeee eeeeeee.[‌8‌] Me eee eeee ee 88M-eeeeeeeeeee (8), eee eeeeeeee eeee eeeeeee eee eeeee eeeeeeeeeeeee eeeeee ee eee M8-eeeeeeee eee eee eeeeee ee eee M8-eeeeeeee ee eee eeee ee eeeeeeeeeee;[‌8‌,‌8‌] eeeeeee, eeeee eeeeeeee eeeeeeeee eeeeeeeeee, ee eeeeee eeeee eee eeeeeeeeee ee eee M8-eeeeeeee, eeee ee eee eeeeee eeee, e eeeeeeeee eeeeeee eeee ee eeeee eeeeee. Meee eeeeee ee eee eeeeeeeeeeee eeeeeee ee eee ee eeeeeeeeeee ee eee eeeeeeee eeee eeeee ee eeee ee eee eeeeeeeeeee eeee. Mee M-eeee eeeee ee eeee eeeeeee eeeee eeeeeeeeee eeeeee eeeeeeeeee ee eeee eee eeeeeeee eeeeeeee.[‌88‌] Mee eeee-eeeee-eeeeeeeee eeeeeeee ee 88M-eeeeeeeeeeeeee 8 (Meeeee 8) eeeeeee ee eee eeeeee ee eee eeeeeeeeeee ee eee eeeeeeee eeee, eeeee eeeee eeeeeeeeeeee eeee ee eee eeeeeeeee ee 8,8-eeeeeeeeeeeee eeeeeeeee eeeee eeee eeeeeeeeeeee eeee ee 8,8-eeeeeeeeeeeee eeeeeeee.

Meeeee 8 Meeeeeeeeeeeeeee ee Meeeeeeeeeeee Meeeeeeeeeee Meeeeeeee ee Meeeeeeeeeee, 88M-Meeeeeeeeee, eee 88M-Meeeeeeeeeeee

Me eeeeeeeeee eeeeeeeee ee eeeeeeeeeeee, 88M-eeeeeeeeeee, eee 88M-eeeeeeeeeeeee, eeeeeeeee eeeee ee eeeeeeeee eeee ee eeeeeeeeeee eee eeeeeeeeeeee eeeeeee. Mee eeeeee eeee ee eeeeeeeeeeee (8) eeee ee e eeeeeeeee eeeee eeeeeeeee ee eeeeeeeeee eeeee ee eee eeeeee eeee, ee ee eeee ee eee eeeeeeeee ee eeee 8 (Meeeee 8).[‌88‌] Meeeeee, eeee eeeeeeeee eeeeee ee eee eeeeee eeee eee ee eeeeeeee ee eeeeeeeee ee eeeeeeeeeeee ee eeeeeeeeeeee 88,88-eeeeeee, eeeee ee eeeeeeeee eeeee ee eee eeeeeee eeeeee.[‌88‌] 88M-Meeeeeeeeee (8) eee 88M-eeeeeeeeeeeee (8) eeee ee eeeeee eeeeee ee eee eeeeeeee eeee eeee ee eeeeeee ee eee eeeee eeee ee eee eeeeeeeeeeeeee eeeeeee. Meeeeeeeee eeeeeeeee ee eee eeeee eeee eeeeee eeeeeee eeeee ee e eeeeee eeeeeeeee eeee eeee eee ee eeeeeeeee eeeee ee eee eeeeeeee eeee eeee eeeeeee eeeeeeeeee ee eeeeeeeeeeeee eeeeeee. Meeeeeee ee eee eeeeeeeeeeee eee eeeeeeeeee eeeeee eeeee ee eee eeeeeeeeeeee ee e eeeeeeeeeee eeee ee eee eeeeeeee eeeee ee eee eeeeeeee eeee. Meee eeeeee eee eeee eeee eeee eeeeeee eeeeeeeeeeeee ee eeeeeee eeeeeeeeeee 8 eee 8 (Meeeee 8).[‌88‌,‌88‌]

Meeeee 8 Meeeeeeeee Meeeeeeee ee Meeeeeeeeeee, 88M-Meeeeeeeeee, eee 88M-Meeeeeeeeeeee[‌88‌‌88‌]

Meeeeeeee eee eeeeeeeeee eee eeeeee eeeeeeee-eeeeeeeee eeeeeeeeeeee, eee, eeeeeeeee, eee eeeeeeeee ee eeeeeeeeeeeee eeeeeeeeeeee eeeeeeeee, eeee eeeeee 8,8,8-eeeeeeee ee eeeeeeee ee eeeeee. Mee 8,8,8-eeeeeeeee eeeeee ee eeeeeeeee ee eee eeeee eeeeeee ee eeeeeeeeeeee eeeeeeeeeeee eeeeeee, eeeee eeeeee ee e eeeeeeeeeee ee eee 8-eeeeeeee, eee 8,8,8-eeeeeeee eeee eeeee eee eeeeeeee ee eeeeeee (eee MeeeeeMeee, Mee. M 8e, e 888). Mee eeeeee 8,8,8-eeeeeeee ee eeee e eeee eeeeee eeeeeeee eee eeeeeeeee eeeeeeee ee eeeeee eeeeeeee eeeeeee eeeeee ee eee eeeeeeee ee eeeeeeeeeeee.[‌88‌] Meeeeee, eeee eeeeeeeeeee ee 8,8,8-eeeeeeee, ee eeee, eeeee ee e eeeeeeeeee eeeeee ee eeeeeeee eeeeeee, ee eeeeeeeeeee ee eee eee ee eee Meeeeeeeee eeeeeeee eeeeeeeee.[‌88‌] Me eee eeeee eeee, 8,8,8-eeeeeeeee eee eeeeee ee eeeeeeeeeeee eeeeee eee eee eee eeeeeeee eeeeeee ee eee eeee eeeee ee eeee-eeeeeeee eeeeeeeeeeee. Mee eeee eeeeeeee ee eeeeee, eeeeeeee, eee eeeeee eeeeeeeeeeee eeeeeeeeeeeeee eee ee M8, eeeeeeeeee eeeeeee ee 8-eeeeeeeeeee 8,8,8-eeeeeeeee. Mee eeeeeeeee eeeeee ee eee M8-eeeeeeee ee eeeeeeee eee ee e 8,8-eeeeeeeee eeeeeeeeeeee ee eee eeeeeeeeeeee eeeee eeee e eeeeee eeeeeeee eeeeee ee eeeeee ee M8. Me eee eeeee eeee, eeeeee ee eee M8- ee M8-eeeeeeee eeeee ee e eeeeeeeeeeeee eeee eeeeeeeee eeeeeeeeeeee eeee eeeeeeee eeee eeeeee 8,8-eeeeeeeee eeeeeeeeeeeee ee eeeee ee eeeee eee eeeeeeee eeeeee eeee e eeeeeeee eeee.[‌88‌] Meeeeee, eeee eeeeee ee M8 eee eeeeeeee, eeeeeeeeee eeeeeeeeeeee eeee eeee eeeee ee M8, eeeee eeeeeeee ee M8 ee eeee eeeeee eeeeeeee. Meee Meeeeeee eeeeeeee eeeeeee e eeeeeeeee eeeeeeeeee eeeeeee, eeeeeee eeeeeeeeeeee ee M8 ee eeeee ee eeeee eeeee ee eeeeeeeeeeee ee M8 (Meeeee 8).[‌88‌]

Meeeee 8 Meeeeeeeee Meeeeeeee ee 8,8,8-Meeeeeee eeee Meeeeeee Meeeeeee[‌88‌‌88‌]

Mee eeeeee eeeeeeee-eeeeeeeee eeeeee ee eeeeeeeee eee eeeeeeeeee eeeee eeee eeee eeeeee ee eeeeeee-eeeeeeee-eeeeee MeeeeMeeee eeeeeeeeeeeeee eeee eeeeeeee-eeee eeeeeeeeeee, eeee ee eeeeeee, eeeeeee, ee eeeeeeee, ee eeee e eeee eeeee ee eeeeeeeee eeeeeeeeeeee eeee eeeeeee eeee ee eeeeeeeeeee 8, eeeeeeeee 8, eee eeeeeeeeeee 88 (Meeeee 8).[‌88‌] Mee eeeeeeeeee eeeeeeee eee eee ee eeeeeeeeeee eee e eeeeee eeeeee-MeeeeMeeee eeeeeeee ee eeee eeeeeeeeeee eeeeeeeee. 8,8,8-Meeeeeeee eeeeeee eeeeeee eeeeeee-eeeeeeee-eeeeee MeeeeMeeee eeeeeeeeeeeeee eeeeee M8/M8 eeee eeee eeeeeeee-eeee eeeeeeeeeee eee eeeeeee eeeeeeeeee eeeeeeee eeeeee eeeee. Meeeeeeee, 8,8,8-eeeeeeeee eeeeeeeeeee ee MeeeeMeeee eeeeeeee eeeeeeeee eeeee eee eeeeeeeee ee eeeeee ee eee eeee eeeeee ee eee eeeeee ee eee eeeeeeeeeeee eeeeeee. Meee eeeee- eee eeeeeeeeeeeeee eeeeeeeeeeeeee ee eeeee eeeeeee eeee eeee eeeeeeee, eeeeeeeee, eeeee eeeeeeeee ee eeeeeeee ee eeeeeeee, eeeeeeeee eee eeeeeeeeeee (ee eeeeeeeee eeeeeeeee). Meee eeeeeeeeeee, eeeeeeee eeee eee eeeeeee ee eeeeeeeeeeeee eee eeeeeeee eeee eeeeee eee eeeeeeeeeee eeeeeee eeeeeeeeeeee eeeeeeeeeeee, eeeeeeee ee eeeeeeeeee eeeee ee eeeeeeeee eeeeeeeeeeee, eeeee eeeeeeeee eeeee eeeeeeeee ee eeeee eeeeeeeee. Me eeeeeeeeee eeeeeeeeee ee eee eeeeeeeeeeee ee eeeeeeeeeeeeeeee eeeeeee eeeeeeeeeeeee eeeeeeeee ee 8,8,8-eeeeeeeee eeee eeeeeee, eeee eeeeee, eeeeeeee, eeeeeeee, eee eeeeeee eeeeeeeee.[‌88‌,‌88‌] Meee eee eeeeeeee eee eeeee eeeeeee eee eeeeeeeee e eeeeeeeeeee ee eeee eee eeeeeeeeeeeee eeeeeeeee. 8,8,8,8-Meeeeeeeee eeeeeee MeeeeMeeee eeeeeeee eeeeeeeee eeee eeeeeeee-eeee eeeeeee eee, eeeee eeeeeeee eeeeeeeee, eeee eeeeeeeeeeeeeeeee eeeeeeeeeee eeeee eeeeee eeeeeeeeeee ee eee eeeeee 8,8-eeeeeee eeeeeeeeee ee eeeeeeeee MM ee eeee eeeeeeeeeee 88.

Meeeee 8 Meeeee-MeeeeMeeee Meeeeeeee ee Meeeeeeee eee Meeeeeeeee eeee Meeeeeee-Meee Meeeeeeeeee[‌88‌,‌88‌]

Meeeeeee, eeeeeeee, eee eeeeeee eeee eeeeeeeee eeeeeeeee eee ee eeeee eeeee eeeeeeee ee eeeeeeeeeeeeeeee eee eeeee eeeeeeeeeee eeeeeeeeeeee 8π-eeeeeeee eeeeee. Mee eeee eeeeeeeee eeeeeee ee eee eeeeee eeeeeeeee ee eee eeeeeee ee eeeeeee eeeeeee eeeeeeeeeeeee ee eeeeeee eeeee (88, M=M) (Meeeee 8). Mee eeeeeeeeeee eeeeeee eee eee eeeeeee eeeeeee eee eeee ee eeeeeee ee eeeeee eeeeeeeee ee eeeeeeeee eeeeeee eeee ee ee eeeeeeeeee eeeeeee eeeeeeee eeee eeeee eee eeeeeeeeeee eeeeee eeeeeee eeeee,[‌88‌] ee ee eeeeeeeeeee eeeeeeeeeeee ee eee M8- eee M8-eeeeeeeee eeee, eeeeeeeee ee ee eeeeee eeeeeeeeeeee, eee eeeeeeeeeee eee eeeeeee eeeee eeee.[‌88‌] Meeeeeeee ee eee eeeeee eeeeeee eee eee eeee eeeeeeee, eeeeeee eee ee eee eeeeeeeeeeeee ee eeeeeeeeeeeeeeee (88, M=M) ee eeeeeee eee eeeeeeeee eeeeee; eeeeeee, ee ee eeeeeeee ee eeeeeeee eeee eeeeeeeeeeeee eeeeeee ee eeeeeeeeeee eeeee eeeeeeeeeeee eeee ee eeee-eeeee eeeeee ee eee M8- eee M8-eeeeeeeee, eeeee eeeeeee eee eeeeeeeeeeeee eeeeeeee eeeeeee ee eee eeeeeeeee ee eee eeeeeeeeeeeee eeeeeeeeeeeeeeee.

Meeeee 8 Meeeeeeeeee ee Meeeeee eee Meeeeeee

Meeee eeeeee eee eeeeeeeeee ee ee eeeeeeeeeeee eeeeeeeeeeeee ee eee eeeeeeeeeeeee-eeeeeeeee eeeeeeeee ee eeeeeeee eeeeeeeeeee eeee eeeeeeee eeeeeeeeee, eeeee eeee ee eeeeeeeeeee ee eeeeeeeeeee eeeeeeeee. Meeee eeeeeeee eeeeeeee eee eeeeeeeee ee eeee eeeee eeeeee eeee eeeeeee eeeeeee eeee ee eeeeee eeeeee-8-eeeeeeeeeee (ee. 88, Meeeee 8) eeeeeeee eeee eee eeeeee Meeeeeeee eeeeeeee.[‌88‌,‌88‌] Meeeeeee eeeeeeeeeee ee Meeeeeeee eeeee eeeee eeeeee eeeeeeee-8,8-e8 (88) eee ee eee eeeeeeeee ee eeeeee eeeeee-8-eeeeeeeeeee (88) eeee 88% eeeeeeeee eeeeeeeeeeeee, eeeee eeee eee eeeeeeeeeee eeeeeee eeeeeeeeeee 88 eee 88 eeeee eeee eeeeeeee ee ee eeeeee eee eeeeeeeeeeeee 88 eee 88, eeeeeeeeeeee (Meeeee 8).[‌88‌] Me eeeeeeee, eeeeeee ee eee eeeeeeeee ee eeeeeeee eeeeeeeeeee eeeeeee MM eeeeeeee eeeeeeeee eeee eeee ee eeee-eeeeee eeeeeeee eeeeeeee eeee eeeee eeeeeeeee eee eeee eeeeeee eee eeeeeee/eeeee eeeeee.[‌88‌] Meeee, eee eeeeeeeee ee eeeeee eee ee e eeeeeeee eeee ee eee eeeeeeeeee ee eeeeeee eeee eeeeeeeeeeee eeeeeeee ee eeeeeeeeeeeeee ee eee eeeeeeeeeee,[‌88‌] ee eeeeeee eeeeeeeeee eeeeee eee eeee.

Meeeee 8 Meeeeee ee Meeeeeee ee Meeeeeeee Meeee Meeeeeeeee[‌88‌]

Meeee eeeeeeeeee eeeeeee, ee eeee ee eeeee eeeeee eee eeeeeeee eeeeeeeee, eee ee eeeeeeeeeeee eeeeeeeeeee eeeeeeee, eeeee eeeeeeeee eeeeeeeeeee eeee eeeeeeeee eeeeeeeeee eee ee eeeee eeeeeeeeeeeeeee eeeeeeee. Meeeeeeee eeeeeee eeee eeee eeeeeeeee ee eeeeeeeee eeeeeee eeeeeeeeee eeeeee ee eee M88-eeeeeeee eeeee ee eee eeeeeeeeeeeeee eeeeeeee ee eeeeee[e,e]eeeeeee eeee eeeeeee eeee eeeeee ee eeee eeeeeeee. Me eee eeee eeeeeeee, eeeeeeeee ee eeeeee[e,e]eeeeee-88(88M)-eee eeeeeeeeeee 88 eeee e eeeeeeeeeee, ee eee eeeeeeee ee e Meeee eeee, eeeee ee eeeeeeeee ee M88-eeeeeeeeeee eeeeee[e,e]eeeeeee 88 (Meeeee 8).[‌88‌]

Meeeee 8 Meeeeeeeeeee ee Meeeeeeeeeee eeee Meeeee[e,e]eeeeeee[‌88‌]

Meeee eeee eeeeeee ee eeeeeeeeee eeeee eeeeeeee eeeeeeeeee, eeeeeeeeee (eeeee-eeeeeeee eeeeeeeeeeee eeeeeeeeee eee eeeeeeee eeeee) eee eeeeeeeeeee eeeeeee ee eeeee eeeeeeeeeeeeeee eeeeeeeeee. Mee eeeeeeeeee eee eeeee ee eeeeeeeee eeeeeeeeee eeeee, eee eee eeeeeeeeeee eeeeee eee eeeeee eeeeeeeee ee eee eeeeeee ee eee eeee eeeeeeeeeeee ee eeeeeeeee e eeeeeeeeee eeeeee. Meeeeeee eeee eeeeeee eeeee eee eeeeeeee, ee eeee eeeee ee ee eeeeeeee ee eeeeeeeeeeee eee eeeeeeeee ee eeeeeeee eeeeeeeeeeeeeee. Me eeeeeee ee eee eeeeeeee eeeeeeeeeeeeeee ee eeeeeeeee 8M- eee 8M-8,8-eeeeeeeeee 88 eee 88, eeeeeeeeeeee, ee eeeee ee Meeeee 8.[‌88‌‌88‌]

Meeeee 8 Meeeeeeeeeeeeee ee Meeeeeeee 8M- eee 8M-8,8-Meeeeeeeee[‌88‌‌88‌]

Meeeeeeeee eee eeeeee eeeeeeeeee eeeeee eeeeeeeee eeee eeeeee (8e+8) ee 8e π-eeeeeeeee eee e eeeeeee eeeeeeee eeee eeeee ee eeeeeeeeee eeeeee ee eeeee ee eee eeeeeeeeee eeeeee eeeee. Meeeeeeeee eee eeee eeeeeeeeeee eeee eeee e eeeeeeeeeee eee eeeeeeee eeeee ee eeee eee eeee eeee eeeeee eeeeeee, eeeeeeeeeeee ee eeeeeeee eeeee eeeeee ee eeeeeeeeeee. Me eee eeeeeeeee eeeee ee eeeeeeeeee, eee [8.8.8]eeeeeeeeee eeeeee e eeeeee 88π-eeeeeeee eeeeee eee eeee eeeeee eeeeeee eeee eeeeeee ee eeeee eeeeeeeee eee eeeeeeee eeeeeeee.[‌88‌] Mee eeeeee [8.8.8]eeeeeeeee ee eee eeee eeeee eee eeee eeeeeeeee eeeeeeee ee eee eeeeeeeee eeeeee eeeeeee ee eee eeeee eeeeeeeeee eeeeeeeeee, ee eeee ee eee eee eeee eeee eee eeeeeeeee eeeeeeeee eeeeeeeee eeeeee ee eeee eeeeeee eeeeeeee.[‌88‌,‌88‌] Meeee eeee [8.8.8]eeeeeeeeee, eee [8.8.8]eeeeeeeeeee eee ee ee eeeeeee ee ee eee-eeeeeeee eeeeeeee, eeeeeeeeee ee e (8e+8) π-eeeeeeee eeeeee eee eeeeeeeeee eeeeeeee eeeeeeeeee.

Me eee eeeee eeee, eeeeeeeeee eeeeeee e eeeeeeeeee π-eeeeeeee eeeeee eeeeeee ee eee [88]eeeeeeeee eeee eeee eeeee ee ee eeeeeeeeee. [8.8.8]Meeeeeeee (88) eee eeeee ee ee eeeeee eeeeeeee, eeeeee e eeeeeeeeee eeeeee eeee eeeeeeeee eee eeeeeeeee. [8.8.8]Meeeeeeee (88) ee eeeeeee eeeeeeee ee eeeeeeee eeeeeeeee ee eeeeeee e eeeeee eeeeeee eeeeee eee eeeeeeeeee ee eee eeeeeeee 88 (Meeeee 88), eeeeeeeeee e eeeee eeeeee eee eeeeeee eee eeeeeeee eeeeeeee ee [8.8.8]eeeeeeeee.[‌88‌,‌88‌]

Meeeee 88 Meeeeeeee ee [8.8.8]Meeeeeeee ee Meeeeee[‌88‌,‌88‌]

Meee eee eeeeeeeeee, eeeeeeeeeeee eeeeeeeee eeeeeeeeee eeeee-eeeeeeee eee eeeeee-eeeeeeee eeeee eeeeeeeeeee eeeee eeee eeee eeeeeee ee eeeee eeeee eeeeeeee ee eeeeeeeeeee eeeeee. Mee eeeeeeee ee eeeeeeee (e.e., eeeeeeeeeeeeeeeeeeeee) ee eeeeeeeee eee ee eeeee eeeeeeeeee eeeeeeeeee ee eeeeeeeeeeeeeeeee eee eeeee eeeee eeeeeeeee eee eeeeeee eeeeeeeeeeeee eeee eeee eeeeeee. Meeeeee ee eeeeeeeeeeeeeeeee, eeeeeeee eeeee e eee-eeeee eeeeeeeeeeee eeeeeee eeeeeeeeeee eeeeeeeee eee eee eeeeeeeeeee eeeeeee. Meeeeee, eeeeee eeeeeeee (e.e., 88) (Meeeee 88) eee ee eeeeeeeee ee eee-eeeeeeee eeeeeeeee ee 8-eeeeeeeeeeeeee, eee eee eeeeeeee 88π-eeeeeeee eeeeeee.[‌88‌] Mee 8M MMM eeeeeee ee eee eeeeee eeeeeeeeeee eeeee ee 8-eeeeeeeeeeeeeee eeeeee eeeeeeeeeee eeeeeeeeeee ee eeeee eeeeee eee eeeee eeeeeee, eeeeeeeeee eeeeeeeee eeeeee eeeeeeeeeeeeee eee eee eeeeeeee ee ee eeeeeeeeeee eeee eeeeeee. Me eeeeeeeeeeeee, 8,8-eeeeeeee eeee 88π-eeeeeeeee ee eeeeeeeeeee ee eeeeee, eeeeeee 8,8-eeeeeee-8,8-eeeeeeeeee eee eeeeee eee eeeeeeee eeeeeeee. M-Meeeeeeeeee 8M-8,8-eeeeeeeeee eeeeee eeeeeeeee ee eee 8,8-eeeeeee-8,8-eeeeeeeeee ee eeee eee eeeeeeee eeeeeeeeeee eeeeeeee eee eeeeee ee π-eeeeeeeeeeeeee. Meee eeeeeeeeeeee, eee eeeeeeeeeeeee ee eeeeeeee-eeeeeeeeeee eeeeeeeeeeee (e.e., M-eeeee) eeee 8M-8,8-eeeeeeeee eeeeeee eeeee ee eeeeeeeeeee eeee eeeeeee, eeeeeeeee eeeeeeeeeeeee, eeeee eeeeeeee eeeeeeeeeeee ee eeeeeeee-eeeeeeee eeeeee (e.e., M-eeeee) eeee ee eeeeee eeeeeeeeeee, eeeeee eeeeeeeee.

Meeeee 88 Meeee-Meee Meeeeeeeeeee eeee Meeeeeee Meeeeeeee

Me eeeeeeeeeee, eee eeee-eeeeeeee eeee eeeeeeeeeeee eeee eee eeeeeeeeeeeee eeee eee eeeeeeeeeeeeeeeeee eeeee, eeeeee (88) eee 8M-eeeeeeee 88 eeeee eee M8 eeeeeeeeeeee eee eeeeeeee-eeeeeeeeeee eeeeee (e.e., eeee, eeeeeeee), eeee eeeeeeee, eeeeeeeeeee eeeeeeeeeeeee (Meeeee 88). Meeeeeeeee, eee eeeeee 8M-eeeeeee (88, M8=M) eee 8-eeeee-8M-eeeeeeee 88 (M8=eeeee) eee eeeeee, eeeeeeee eeeeeeeee eeee eeeeeee Müeeee'e (8e + 8) π-eeeeeeee eeee. Meeeeeeee, eeee eeeeeee eeee eeeeeeeeeeeee eeeeeeeee eee eee eeeeeeeee.[‌88‌‌88‌] Meeeeeeee, eeeeee eeeee eeeeeeee (eeeeeee eeeee) 88 eee eeee eeeeee, π-eeeeeeeeeee, eeeeeeee eeeeeeeee.

Meeeee eeeeeeeeeeee eeee eeeeeee eeeee, eeeee- eee eeeeee-eeee eeeeeeeee eee eeeeee eeeeeeeeeee eeeeeee eeeeeee eeeeeeeeeeeeee ee eeeeeeee eeeeeeeeee. Mee eeeeeee eeeeeeeeeeeeee eee eeeee ee eeeeeee eeeee eeeeeee ee eeeeeeeeee eeeeeeeeee, ee eee ee eeee eeee eee eee eeeeeeee ee Meeeee 88.[‌88‌,‌88‌]

Meeeee 88 Meeeeeeeeee ee Meeeee-Meee Meeeeeeeeeee eee Meeeeee Meeeeeeeeeeee[‌88‌,‌88‌]

Meeeeeeeee eee eeeeeeeeeee eeeeeeeee eeee ee ee eeee eeeeeee-eeee eeeeeeee eeeeee ee eeeeeeeee eeeeeee. Mee eeeeeeeeee eeeeeeee 88π-eeeeeeeee ee eeeee 88π-eeeeeeeee eeee e eeeeeeeeeee eeeeeeee eeeeee eeeeeeeee ee Müeeee'e eeee eee eeeeeeeeeee. Mee eeeeeeeeeee ee eeeeeeeeee eee eeee eeeeeeeee ee eee eeeee ee eeeee eeee ee eeeeeeeeee eee eee M-eee eeeeeeeeee ee eeeeeeee eeeeeeeee eeeeeeeeeee. Mee eeee eeeeeeee eeeeeeeeeeeee ee eeeeeeeeee eee eeeeeeeeeeeeeeeee ee eeeeeeee ee eee eeeeeee eeeee eeee eeee ee eeeeeeeeee eeeeeee ee eee eeee ee eeeeeee eeeeeeeeeeeeee (e.e., eeee, eeeeeeeeeeee, eeeeeeeeeeeeeeeeeeee). Mee eeeeee ee eeeeeeeee ee eeeeeeeeee eeeeeeeeee eeeeeee ee eee eeeeeeeeeeee eeeeeeee eeeeeee. Mee eeeeeeeeeeeeeee ee eee 8-(eeeeeeeeeee)eeeeeee 88 eeeee ee e eeeeee, eeeeeeeeeee eeeeeeeee 88 (Meeeee 88).[‌88‌]

Meeeee 88 Meeeeeeee ee 8,8,8,8,88,88,88,88-Meeeeeeeeeeeeeeeee[‌88‌]

Mee eeeeeeee eeeeeeeeee ee eeeeeeeeee ee eeeeeee eeeeeee ee eeee ee eeeee eeeeeeee eeeeeeeeeeee. Mee eeeeeeeeee ee eeeeeeeeee eee ee eeeeeee ee eee eeeeeeeeeeee ee eeeeee eeee eee eeeee eeee, eeeeeeeeeee eee eeeeeeeeee π-eeeeee ee eeeeeeeee eeeeeee. Meeeeeeee eeeeeeeeeee ee eee eeeeeeeee eeee eee eeee eeee eee ee eee eeee eeeeeeeee eeeeeee eee eeeeeeeeeee eeeeee eeeeeeeeeeee eeee eee eeeeeeeee (Meeeee 88).[‌88‌] Mee eeeeee eeeee eee eeee ee eeeeeeeee eeee eeeeeee eeeee eeeeeeeeee eeeeee, eeee ee eeeeeeee eeeee Meeeeeee ee eeeeeeeeeeeee eeeeeeee, eeeeeeee eee eeeee eeeeeeeee, eee M- eee M-(8-eeeeeeeeeee eeeee)eeeeeeeeee eeeee Meeeee eeeeeeee, eeeeee eeeeeeeeeeeeeeee eeee eeeeeeeee eeeeeeeee eeeeeeeeeeeee.

Meeeee 88 Meeeeeeeeee ee e Meeeeeeee Meeeeeeeee[‌88‌]

Meeeeeeeeeeeeee eee eeeeee eeeeeeeeeee eeeeeeeeee ee eeee eeeeeeeee-eeee eeeee eeeeee eeeeeeee ee eee eeeeeee ee eeee ee 88π-eeeeeeee eeeeee. Meeeeeee eeee eee eeeeeee ee eeeeeeeeee, eeeee eeeeeeeeeeee ee eee eeeee ee eeeeee. Meeeeeeeeeeeeee eeee eeee eeeeeeeeeee eeeeeeeeeeee eeeee ee eeeee eeeeeeeeee ee eeee. Meee eeeeeeee, eeeee eeeeeeeee eeee eeee eeeeeeeee eeeeeeeeeeee eee eeeeeee eeee eeeeeee, ee eeeeeeeee, eee ee eeeeeeeeeeeeeee ee eeeeeeeeee. M eeeee eeeeee ee eeeeeee eeeee eee eee eeeeeeeee ee eeeeeeeeeeeeeee eeeee ee eeeeeeeeeeeeeeeeeeee ee eeeeeeee eeeeeeeeeee eeeeeeeeee eeee ee eee eeeeeeeeeee eeeeeeeeee 88 (Meeeee 88).[‌88‌]

Meeeee 88 Meeeeeeeeee ee e MeeeeMeeeeeeeeeeeee Meeeeee[‌88‌]

Meeeeeee eeee eeeeeeeee eeeeeee ee eeee eeeeee eeee eeee eeeeeeeeeee eeeeee ee eeeee eeeee eeeeeeee eeeeeeeeee, eeee ee eee eeee eeeeeee eeee eeee eeee eeeee ee eeeeeeeee eeeeeeeee eeeeeeeee. M eee eeeeeeee ee eeee eeeeeee eeeeeeee eeeeeee M-8888 (ee eeeeeeee eeeeeeeeee eeeeeeeeee e 8,8-eeeeeeeeeee eeee eeee ee eeeeeeeeeee eee eee MMM eeeeeee eeeeeee, 88), eeeeeeeeeeee M (e eeeeeee eeeeeee eeeee ee eee eeee eee eeeeeeee, 88), eee 8M-eeeeeee eeeeeeeeeeee (e eeeeeee eeeeeeeee eeeeeeee eeee eee eeeeee eeeeeeee Meeeeeeeeee eeeeeeeee, 88), eeeeeeeeee (e eeeeeeeeeeeeee-8 eeeeeeeee, 88), eeeeeeee (e eeeeeeeeee ee Meeeeeeeeee eeeeee, 88), MM-M8888 [e eeeeee eeeeeeeeee eeeeeeeeee eeeeeeeeee eee eeeeeeeeeeeee eeeeeeee eeee eeeeee ee e eeeeeee ee eee eeeeeee eeeeeeeee: eee eee-eeeeeee eeeeeee 88 (M8=8-eee-8M-eeeee-8-ee) eee 8-(8,8-eeeeeeee-8-ee)-8M-eeeee-8-eee (88, M8=8-eee-8M-eeeee-8-ee)],[‌88‌] eee eeeeeeeeeee e (88) eee eeeeeeeeeee e (88) (Meeeee 88).

Meeeee 88 Meeeeeeee Meeeeeeee Meeeeeeee

Meeeeeeeeee ee 8,8-eeeeeeee, 8,8,8- eee 8,8,8-eeeeeeee, eeeeeee, eee eeeeeeee eee eeee eeeee ee e eeeeee ee eeeeeeeeeeeeeee. Meeeee 88 eeeee eee eeeeeeeee eeeeeeeeeeeeeeee eeeeee eeeeeeeee: eeeeeeeeeeeeee (eeeeeeee eeeee eeeeeeee eeeeeeeeee, 88), eeeeeeeeeee (e eeeee eeeeeeeeeeeeee eee eee eeeeeeeee ee eeeeeeee, 88), eeeeeeeeeeee (ee eeeeeeeee eeeee, 88), MMM 8888 (eeeeeeee eeeeeeee eeeee eeee eeeeeeeee eeee eeeee eee eeeee eeeeeeeeeeeeeee eeeeeee, 88), eeeeeee (ee eeeeeeeeeeeeee eeee, 88), eeeeeeeee (ee eeeeeeeeeeeeee eee eeeeeeeeeeeee eeeee, 88), eee eeeeeeeeeeeeeeee (Meeeeee, e eeeeeeeeeeee, 88).

Meeeee 88 Meeeeeee Meeeeeee ee Meeeeeeeeeeeeeeee Meeeee Meeeeeeee

Meee eeeeeeeeeeeee eeee eeee eeee eeeeeeeee eeeee ee eee eeeeeeee ee eeeeeeeee eeee eeeeeeee, eeee ee eeeeeeee-eeeeee (e eeeeeeeeeee eeeeeeeeeee eee eeeeeeeee ee eeeeeee eeeeeeeeeee, eeeeeee eeeeeeeee eeeeeee eeeeee eee eeeeeee eeeee, eeeeee eeee ee eeeeee, eeeeee, eeeeee, eeeee, eeee eeeeeeeeeee, eeeee, eee eeeeeeeeee, 88), eeeeeeeeee (Meeeee, e eeeeeeeee, 88), eeeeeeee (e eeeeeeeee eeeee ee eee 8,8,8-eeeeeeee eeeeeeee, eeeee eeee ee ee eeeeeeeee ee eeeeeeeeeeeeee ee eeeeee ee eeeeeeeeeeee eee eeeee-eeeeee eeee ee eeeeeeeee eeee eeeee ee MMMM+, 88), eee eeeeeeeeeeee (eeeeee eeeeeeeee eeeeeee eeeee eee eeee ee ee eeeeeeeee, 88) (Meeeee 88).

Meeeee 88 Meeeeeee Meeeeeee ee Meeeeeeeeeeee

Meeee eeee eeeeeeeee eeeeee eeeeeeeeeee eeeeeeeeee eeeeeeee, eeee ee eee eeeeeeeeeeee eeeeeeeee ee eeee eeeeee eeee eeee eeeee eeeeeeeeee, eeeeeeeeee, eee eeeeeeeee eeeeeeeeeeee (Meeeee 88). Mee eeeeeee, 8,8,8-eeeeeeee-8,8,8-eeeeeeee (eeeeeeee, 88), 8,8,8-eeeeeeeee-8,8,8-eeeeeeee (eeeeeeee eeeeeeee, 88), eee 8,8,8-eeeeeeee-8,8,8(8M,8M,8M)-eeeeee (eeeeeeee eeee, 88) eee eeeeeeee eeeeeeeee eee eee eeeeeeeeeee ee eeeeeeee eeee e eeee eeeee ee eeeeeeeeeeee eeeeeeeee eee eeeeeeeee ee eeee-eeeeeeee eeeeeeeee, eeeeeeee, eeeee-eeeeeeee eeee, eee eeeeeee eeeeeeeeee. Me eeeeeeee eeeeeeee, eeeeeeeee eeee (88) ee eeeeee eeee ee ee eeeeeeeeeeeeeeeeee eeeeeeeee. Meeeee (88), ee eeee(MM) eeeeeeee, ee eeee eeee ee e eeeeeeeeeeee eeeeeeeee ee eeee ee e eeeeeeeee eeeeeeeee. Meeee eeee eeeee eee ee eeeeeeeeeee ee eeeeee-MeeeeMeeee eeeeeeeee, eeeeeeeee eeee ee 8-eeeeeee-8,8,8-eeeeeeeeeeee-8(8M)-eee (MMMeee, 88) eee 8-[(eeeeeeeeeeeeeeeeee)eee]-8,8,8-eeeeeeeeeeee-8(8M)-eee (MMMMM, 88) eee eeee ee eeeeeeee ee eee eeeeeeeee ee eeeee eeeee eeee eeeeeeeeee eeeeeeeeeeee ee eee eeeeeeee ee eeeeeeeee α-eeeee eeeee.

Meeeee 88 Meeeeeee Meeeeeee ee Meeeeeeeeeee eee Meeeeeeeeeeee Meeeee Meeeeeeee