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17.2.3.1.1.2.3.7 Method 7: Reaction of 1-Carboximidoylguanidines with Carboxylic Acid Derivatives

DOI: 10.1055/sos-SD-017-00728

von Angerer, S.Science of Synthesis, (200417502.

A versatile procedure for the synthesis of 4,6-disubstituted 1,3,5-triazin-2-amines 147 is the reaction of 1-carboximidoylguanidines 146 with acid chlorides or esters (Scheme 84). Acid chlorides react in acetonitrile at room temperature to give the triazines in high yield whereas the esters must be refluxed in ethanol for cyclization.[‌300‌‌302‌]

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