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17.7.2 Product Subclass 2: [2.2.3]Cyclazines (Pyrrolo[2,1,5-cd]indolizines) and Related Compounds

DOI: 10.1055/sos-SD-017-01619

Tominaga, Y.Science of Synthesis, (2004171026.

[2.2.3]Cyclazines generally consist of aromatic (4n+2)π-electron systems, containing 10π-electrons, and have been studied with respect to their stability and chemical behavior.[‌5‌,‌6‌,‌8‌,‌10‌] Consequently, much attention, from a theoretical and a practical standpoint, has been directed to the synthesis and properties of a series of these compounds, especially the parent compounds. [2.2.3]Cyclazine, which represents a wide range of cyclazines, includes the most interesting compounds with regard to cyclazine chemistry, and many of its derivatives have been prepared. The basic structures of [2.2.3]cyclazine derivatives such as 1618 are shown in Scheme 3.[‌5‌,‌6‌,‌8‌,‌10‌]

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