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17.7.4.1.3.1.2.1 Method 1: Thermolysis of a Pyrido[2,1,6- de]quinolizine-4,5-dicarboxylate

DOI: 10.1055/sos-SD-017-01619

Tominaga, Y.Science of Synthesis, (2004171060.

When tert-butyl esters 138 (prepared from 129 as in Section 17.7.4.1.1.1.1) are used, the products can be thermolyzed to give the parent [3.3.3]cyclazine (4) (Scheme 53) or its 1-alkoxycarbonyl derivatives.[‌130‌,‌131‌] The cyclazine diesters are readily hydrogenated to give tetrahydro derivatives.

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