You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via18.6.5.1.2.4.1 Variation 1: Hydrolysis of Thiocyanates
Please login to access the full content or check if you have access via
Rossi, L., Science of Synthesis, (2005) 18, 613.
The reaction of thiocyanates with concentrated sulfuric acid and ice water gives the corresponding thiocarbamates 313 (Scheme 220). The reaction proceeds smoothly with aromatic[523] and primary aliphatic thiocyanates,[524,525] but secondary thiocyanates are less reactive. tert-Butyl thiocyanate is not reactive at all. In addition, the reaction is unsatisfactory in the case of several 2-substituted phenyl thiocyanates which are sensitive to concentrated sulfuric acid.
Meeeee 888 Meeeeeeeee ee Meee Meeeeeeeeeee[888]
Meeeeeeeeeee Meeeeeeee
M-(8-Meeee) Meeeeeeeeeeee (888, Me8 = 8-Mee); Meeeeee Meeeeeeee:[888]
8-Meeee eeeeeeeeeee (88–88 eeee) eee eeeeeee eeeeee, eeee eeeeeee eee eee eeeeeee, eeee eeeee 88% M8MM8 (88 eM). Mee eeeeeee eee eeeeeee ee eeeee ee 8–8°M eee 88 e, eee eee eeee eeeeee eeee eee. Mee eeeeeeeeeee eee eeeeeeeee, eeeeee eeee M8M, eee eeeee ee eee, ee ee eeee eeeee eeeee eeeeeee eeeeeeee eeee eeeeee eeeeeee. Me e eeee-eeeeeee eeeeeee eee eeee eee eeeeeeeeeeeeeeeee, e eeee eeeeeee eeeeee eee eeeeeee ee eeeee ee eeeeeee eeeeeeeeeeeee ee eee eeeeeee; eeeee: 88%; ee 888°M (eee).
References
| [523] | Meeeeeeeeeeee, M.; Meeeee, M.; Meeeee, M., M. Me. Meee. Mee., (8888) 88, 8888. |
| [524] | Meeeeee, M.; Meeeee-Möe, M., M. Me. Meee. Mee., (8888) 88, 8888. |
| [525] | Meeeeeeeeeeee, M.; Meeeee, M., Meeee. Meee., (8888) 88, 888. |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) 8, 888.
- 8.Meeeee-Meee, (8888) M 8, 888.
- 8.Meeeee-Meee, (8888) M 88-8, 88.
- 8.Meeeee-Meee, (8888) M 8e, 888.
Return to Top