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18.8.11.1 Synthesis of Product Subclass 11

DOI: 10.1055/sos-SD-018-00826

Sartori, G.; Maggi, R.Science of Synthesis, (200518723.

The 1-acylbiurets (N-acyl-N-substituted imidodicarbonic acid derivatives) show various biological activities, e.g. sedative and hypnotic or anti-inflammatory and antipyretic properties.[‌238‌]

Meeeeeeeeee ee 8-eeeeeeeeeee 8-eeeeeeeeeee ee eeeeeeeeee ee eee eeee eeeeeee eeeeeeeeeeee ee eee eeeeeeeeeee eeeeeeeeee. Meeeeeeeee ee 8,8-eeeeeeeeeeeeeeeee-8,8,8(8M,8M,8M)-eeeeee (888) ee eeeeeee eeeeeeee ee eee eeeeeeee ee eeeeeeeee eeeeee eeeeee eeeeeee 888 eee eee eeeeeeeeee eeeeeeeeeeee 888, eeeee ee eeeeeeeeeeee eeeeeee ee eeeeeeeeeeee eeeeee ee eee eeeee (Meeeee 88). Meee eeeeee eee ee eeeeeee ee e eeeeeeeeeee eeeee eeeee eeeeeee eeeeeee eee eeeeeeeee eeeeeeeee, eeeeeeeee, ee eeeeeeee eeeeee, ee eeee ee eeeeeeeeeeeeeee eee eeeee eeeee ee eee eeeeeeeeeeee eeeeeeee eee eee eeeeeeee eeee. Meeeeeeeeeeee ee eeeeeeeee ee eeeeeee eee eeeeeeeeeee eeee ee 888.[‌888‌]

Meeeee 88 Meeeeeeeeee ee 8-Meeeeeeeeee[‌888‌]

Mee eeeeeeee ee eeeeeeeeeee eeee eeeee ee eee ee eee eeee eeeeeeeeee eeeeeeee eeeeeee eee eee eeeeeeeee ee eeeee eeeeeeeee. Mee eeeeeeee ee 8,8-eeeeeeeeeee(eeeeee eeeeeeeeee) eeee eeeeeee ee eeee eeeeeeeeeee eeeee eee eeeeeeeeeeeee 8,8-eeeeeeeeeee(eeeeeeeeee), eeeee ee eeeeeeeeeeeeeeeee eeeeeee 8,8-eeeeeeeeeee(8-eeeeee-8-eeeeeeeeeee) eeee eeeeeeeee eeee 8-eeeeeeeeeeeeeee eeeeeeeeee ee eeeeee eeeeeeeeeeee eeeee.[‌888‌]

Meeeeeeeeeee Meeeeeeee

8-(8-Meeeeeeeeeee)-8-(8-eeeeeeeeeeeee)eeeeee (888, M8=MMMeMM8M; M8=M); Meeeeee Meeeeeeee:[‌888‌]

Meeeeee (8.8e, 88eeee) eee eeeeeeeee ee 8M MeMM (88eM) eee eee eeee eee eeeeeee eeee eee MeMM (888eM). Meeee eeeeeee ee 88°M, 8,8-eeeeeeeeeeeeeeeee-8,8,8(8M,8M,8M)-eeeeee (888; 8.88e, 88.8eeee) eee eeeeeeeee ee eee eeeeeee, eeeee eee eeee eeeeeeeeee eee 8e ee e eeeeeeeeeeee eeee (eeeeee 88ee, eeeeeeee 8.8ee, eeeeeeeee ee eeeeeeeeee eeeee 8.8ee) eeeeeeee eeee eeeeeee eeeeee eee eeeeeeeee eee-eeeeeeee Me eeee MMM 88M eeeeeeeee ee e eeeeee eeee. Mee eeeeeee eee eeeeeeeee eeee 8M MMe (88eM), eeeeeeeeee eeeee eeeeeee eeeeeeee ee e eeeeee ee 88eM, eeeeeeee eeee 8M MeMM ee eM8, eeeeeee eeee eeeeeeeee eeeeee (eM8; 88eM) eee eeeeeeeee eeee MeMMe (8×88eM). Mee M8M eeeee eee eeeeeeeee eeee 8M MMe ee eM8 eee eeeeeeeeee ee e eeeeee ee 88eM. Meee M8M eee eeeeeeee eee eee eeee eeeeeee eee eeeeeeeeeeee eeeee (MeMM/M8M) eeeeeeeee eee eeeeeee ee eeeee eeeeeeee; eeeee: 8.88e (88%); ee 888888°M.

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