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18.10.8.1.6 Method 6: From Thiocarbonyl Transfer Reagents

DOI: 10.1055/sos-SD-018-00970

Sato, S.; Furukawa, N.Science of Synthesis, (200518905.

Reactions of primary or secondary amines with thiophosgene or isothiocyanates are used widely as a synthetic method for the synthesis of thiourea derivatives. However, these methods are hazardous due to the toxic properties of both thiophosgene and isothiocyanates. Despite their toxicity, these reagents continue to be widely used due to the importance of symmetrical and unsymmetrical thioureas. On the other hand, preparative methods involving the use of thiocarbonyl transfer reagents are more efficient and safer.

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MM8MM=MM8 88 88 [‌888‌]
(MM8)88Me 88 88 [‌888‌]
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(MM8)8Me 88 88 [‌888‌]
Me 88 88 [‌888‌]
Me 88 88 [‌888‌]
8-MeMM8M8(MM8)8 88 88 [‌888‌]
8-eeeeeee 88 88 [‌888‌]
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Meeeee 888 Meeeeeeeeeeee Me- eee Meeeeeeeeeeeee Meeeeeeee[‌888‌]

Meeeeeeeeee 888

M8 M8 M8 Meeee (%) Mee
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Me 8-MeMM8M8 M 88 88 [‌888‌]
Me 8-eeeeeee M 88 88 [‌888‌]
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M-Meeeee-8M-8,8,8-eeeeeeee-8-eeeeeeeeeeeeee (888):[‌888‌]

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8-Meeeee-8-eeeeeeeeeeeeee (888, M8=Me; M8=Me; M8=M8=M); Meeeeee Meeeeeeee:[‌888‌]

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8-Meeeee-8-eeeeeeeeeeeeee (888, M8=Me; M8=Me; M8=M8=M):

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References


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