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Please login to access the full content or check if you have access via18.15.1.2.4 Method 4: Synthesis of Trimethyl(trifluoromethyl)silane (Ruppert's Reagent)
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Il'chenko, A. Y., Science of Synthesis, (2005) 18, 1143.
Trimethyl(trifluoromethyl)silane (25) (bp 45°C) is a reagent that can be used for the introduction of the trifluoromethyl group under mild conditions.[78–80] It can be prepared from bromotrifluoromethane (5), hexaethylphosphorous triamide, and chlorotrimethylsilane (Scheme 16);[78,79] from trifluoroiodomethane (9), tetrakis(dimethylamino)ethene, and chlorotrimethylsilane (Scheme 16);[78] or from bromotrifluoromethane (5), chlorotrimethylsilane, and aluminum (Scheme 16).[81] The use of trimethyl(trifluoromethyl)silane (25) in the trifluoromethylation of a carbonyl compound in the presence of the fluoride ion is illustrated in Scheme 16.[78]
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Meeeeeeee(eeeeeeeeeeeeeee)eeeeee (88):[88]
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References
| [78] | Meeeeeeeeeee, M.; Meeeee, M. M.; Meeeeee, M. M. M., M. Mee. Meee., (8888) 88, 888. |
| [79] | Meeeeee, M.; Meeeeee, M.; Meeeeeee, M., Meeeeeeeeee Meee., (8888) 88, 8888. |
| [80] | Meeeeee, M., M. Meeeeeee Meee., (8888) 88, 888. |
| [81] | Meeee, M.; Meeee, M., Meeeeee, (8888), 888. |
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- 8.Meeeee-Meee, (8888) M 88e8, 888.
- 8.Meeeee-Meee, (8888) M 88e8, 888.
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