0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via Method 3: From Aryl Halides

DOI: 10.1055/sos-SD-019-00127

Subramanian, L. R.Science of Synthesis, (200419179.

Aryl cyanides are fundamentally important compounds in organic synthesis and also serve as crucial fine chemicals in the applied industrial synthesis of many agrochemicals, natural products, pharmaceuticals, dyes, herbicides, and liquid crystals. Conventional preparation of aryl cyanides by nucleophilic aromatic substitution of aryl halides on unactivated aromatic rings is best effected by copper ligand exchange reactions. The order of reactivity (Ar1I > Ar1Br > Ar1Cl > Ar1F) is consistent with the strength of the Ar1X bond. Among these aryl halides, aryl chlorides are inexpensive and readily available in bulk quantities. Therefore, many reports have focused on the conversion of the Ar1Cl bond into the Ar1CN bond.[‌29‌]

Meeee eeeeeeeee eee eeeeee eeeeeee eee eeeeeeee eeeeeeeeeeeeeee eeee-eeeeeee, ee eeeeeeee eeeeeeeee eee eeee eee eeeeeee. Me ee eeeeeeee eeee eeee eeee eee eeeeeeeee eeeeeeee ee eeeeeeee eeeeeeeee,[‌88‌] eeeeeeeee eeeeeee eeeeeeeeee.[‌88‌] Me eee eeeeeeeee ee eeeeeee eeee eee eeeeeeee eeee ee eeeeeeeee ee eeeeeeeee ee eeeeee e σ-eeeeeee eeeeeee eee eeeeee eeeee eee eee eeee eeeee ee eee eeeeee, ee e π-eeeeeee eeeeeee eee eeeee eeeeeee eee eee eeeeeeee eeee. Meee ee eeeeeeee ee eeeeeeeeeeee eeeeee ee eee eeeeeee eeeee, eeeeeee ee eeeeeeeeeeee ee eee eeeeee.

Meeeeeeee-eeeeeeeee MM eeee-eeeeeee eeeeeeeee eeeeeeeee eeeeee eeeee ee eeee eeeeeeee eeee eeee eeeeeeeee ee eeeeeeeee eeeeeeeeee eee eee eeeeeeeeee ee eeee eeeeeeee eeee eeeeeee. Meeee eeee eeeeeeeeeeeeee eeeeeeee ee ee eeeeeeeeee eeeeeeeee eeeeeeeee, eeee eeeeeee eeeeeeee eeeee ee eee eeeeeee eee eeeeeeee eeee eeee eeee eeeeeeeeee.