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Please login to access the full content or check if you have access via Variation 7: Reaction of Active Methylene Compounds Bearing a Cyano Group with Carbonyl Compounds (Knoevenagel Reaction)

DOI: 10.1055/sos-SD-019-00220

Murahashi, S.-I.Science of Synthesis, (200419351.

Reaction of active methylene compounds (XCH2Y) with carbonyl compounds (the Knoevenagel reaction) is applicable to any aldehyde or ketone, although harsh conditions may be required with some less reactive methylene groups.[‌47‌‌50‌]

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