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Please login or sign up for a free trial to access the full content. Variation 1: Base-Catalyzed Hydrolysis

DOI: 10.1055/sos-SD-020-00045

Jain, N. F.; Masse, C. E.Science of Synthesis, (20072080.

Typical conditions for the base-catalyzed hydrolysis of simple amides involve refluxing the amide in an aqueous solution containing approximately 20% sodium hydroxide. More forcing conditions involve the use of potassium hydroxide in mono-, di-, or triethylene glycol. Some examples are shown in Table 3.[‌42‌‌46‌]

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