Science of Synthesis

Lin, S.; Yan, L.; Liu, P., Science of Synthesis, (2007) 20, 106.

Polymer-supported chlorite[‌10‌] can be obtained readily from Amberlyst IRA 900 by ion exchange with sodium chlorite. This reagent is used for the conversion of many aldehydes into their respective carboxylic acids ‌47‌ in excellent yields, without any need for conventional workup procedures (‌Scheme 16‌). In addition, many common protecting groups, such as silyl, benzyl, or tetrahydropyranyl ethers, tert-butoxycarbonyl, benzyloxycarbonyl, acetyl, or acetonide units, survive the conditions of the oxidation. Significantly, α,β-unsaturated aldehydes and epoxy aldehydes can also be converted into the corresponding acids without degradation by this procedure.

‌Meeeee 88‌ Meeeeeeee ee Meeeeeeee ee Meeeeeeeee Meeee ee Meeeeee-Meeeeeeee Meeeeeee[‌88‌]

‌Meeeeeeeeee 88‌

M8	Meeeee (%)	Mee
(M)-MM=MMMe	88	[‌88‌]
(MM8)8Me	88	[‌88‌]
(MM8)8MMMMMM	88	[‌88‌]
(MM8)8MMe	88	[‌88‌]
(MM8)8MMMM	88	[‌88‌]
(MM8)8MMMee	88	[‌88‌]
(MM8)8MMMee	88	[‌88‌]
	88	[‌88‌]
(MM8)8MM(MMe)MM8MMe	88	[‌88‌]
	88	[‌88‌]

e Meeeeeee eeeeee.

Meeeeeeeeeee Meeeeeeee

Meeeeeeeee Meeee ‌88‌; Meeeeee Meeeeeeee:[‌88‌]

Meeeeee-eeeeeeeee eeeeeeee (Meeee, <8 eeee·e−8, 88 e) eee eeeeee eeee M8M (888 eM). Mee eeeee eee eeeee ee 8 M MeMeM8 (888 eM) eee eee eeeeeee eee eeeeee eee 88 e ee 88°M. Mee eeeeeeee eeeee eeee eeeeee eee eeeeeeeee ee eeeeeeeeee, eee eeeeee eeeeeeeeeeee eeee M8M (8 × 88 eM), MMM (8 × 88 eM), eee Me8M (8 × 88 eM); eeeee: 88.8 e.

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References