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20.2.1.6.5 Method 5: Metalation–Carboxylation Reactions

DOI: 10.1055/sos-SD-020-00172

Evano, G.Science of Synthesis, (200720231.

Unactivated alkenes can react with organometallic reagents to generate a new metallic species that can further react with carbon dioxide or an equivalent to produce a carboxylic acid. The reactions between the organometallic reagent and the alkene can be divided into two different classes: hydrometalation (if the organometallic reagent is used to add a hydrogen atom in the substrate) or carbometalation (if it is used to add an alkyl group atom).


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