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20.2.1.7.5 Method 5: The Benzil–Benzilic Acid Rearrangement

DOI: 10.1055/sos-SD-020-00195

Phillips, A. J.; Love, C. E.Science of Synthesis, (200720259.

The rearrangement of benzil (30, R1=R2=Ph) to benzilic acid (31, R1=R2=Ph) has been known since 1838, and in its most general form this rearrangement involves the base-mediated rearrangement of an α-diketone to an α-hydroxy acid.[‌92‌,‌93‌] The reaction is most commonly employed with bisaromatic diketones, and representative examples of this type of rearrangement are shown in Scheme 26.[‌94‌‌99‌]

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