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20.2.1.8.6.4 Variation 4: Asymmetric Hydrogenation

DOI: 10.1055/sos-SD-020-00203

Vedantham, P.; Jiménez, M.; Hanson, P. R.Science of Synthesis, (200720286.

The asymmetric hydrogenation of double bonds requires the use of a chiral catalyst that can distinguish between the two faces of the alkene. The most commonly used chiral catalysts are [(R)-2,2-bis(diphenylphosphino)-1,1-binaphthyl]ruthenium(II) complexes. However, rhodium(I) perchlorate complexes have also been used successfully for the asymmetric hydrogenation of α,β-unsaturated carboxylic acids.

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