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Please login to access the full content or check if you have access via20.2.10.1.1.3 Variation 3: Carboxylation of Phenols by Carbon Tetrachloride
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Yoon, T. P.; Jacobsen, E. N., Science of Synthesis, (2007) 20, 535.
Treatment of a phenol, such as 3, with carbon tetrachloride and copper powder under alkaline conditions results in the formation of hydroxy acids, e.g. 4 (Scheme 3).[13] The regioselectivity of this process is generally lower than that observed in the Kolbe–Schmitt reaction, although the use of a cyclodextrin catalyst (β-CD; Scheme 3) can improve the selectivity to provide very good yields of the para-isomer, e.g. 4-hydroxybenzoic acid (5).[14]
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References
| [13] | Meeeeee, M. M.; Meee, M., M. Me. Meee. Mee., (8888) 88, 8888. |
| [14] | Meeeeeee, M.; Meeee, M., M. Me. Meee. Mee., (8888) 888, 888. |
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