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Please login to access the full content or check if you have access via20.4.1.1.2.1 Variation 1: Via Acid Chloride Intermediates
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Keller, P. A., Science of Synthesis, (2007) 20, 617.
The conversion of carboxylic acids into intermediates that are more susceptible to nucleophilic attack by carboxylic acids is a much more synthetically useful strategy to access anhydrides. This allows for the synthesis of symmetrical and mixed anhydrides under relatively mild conditions, with an extensive range of possible intermediates to choose from.
Mee eeeeeeeeee ee eeeeeeeeee eeeee 8 eee 8 (Meeeeee 8 eee 8) eeee eeeee eeeeeeeeeeeee eeee eeeeeeeee eeeeeee e eeeeee eee eeee eeeeeeeee ee eeeeeeeeee 8 eee 8, eeeeeeeeeeee, ee eee eeeeeeeeee eeeeeeee ee eeeeeee eeeeeeeeeee ee eee eeeeeeeeee eeee. Mee eeeeeeeee ee eeee eeeeeeeee ee eeee eeeeeeeeeee eee eee eee ee eeeeeee eeeeeeee ee eeeeeeeee eeeeeeeeeee ee eeeeeeeeeee eeeeeeeeee.[8] Mee eee ee eeeeeeee ee eee eeeeee eeeee ee eeeeeeee; eee eee ee e eeee eeeeeeeee eeeeee eee e eeeeee eee eeeeee eeeeeeee (Meeeee 8)[8–8] eeeeeeee ee eee eeeeeeee eeeeeee e eeee (Meeeee 8).[8]
Meeeee 8 Meeeeeee ee Meeeeeeeee Meeee eeee Meeeeee Meeeeeee eee Meeeeeee[8–8]
M8 | Meeee (%) | ee (°M/Meee) | Mee |
---|---|---|---|
Me | 88 | 888/888 | [8] |
Me | 88 | 888–888/888 | [8] |
e-Me | 88 | 888–888/88 | [8] |
(MM8)8Me | 88 | 888–888/8.8 | [8] |
Me | 88 | 88/888 | [8] |
Meeeee 8 Meeeeeee ee Meeeeeeeee Meeee eeee Meeeeee Meeeeeee ee eee Meeeeee ee Meeeeeee[8,88,88]
M8 | Meeeeee | Meee (e) | Meeeee | Meeee (%) | ee (°M) | ee (°M) | Mee |
---|---|---|---|---|---|---|---|
Me | – | 88 | eeeeeeeeee eeeeeeeeeeee | 88 | – | 888 | [8] |
e-Me | eeeeeee | 88 | eeeeee eeeeeeeeeeee | 88 | – | 888 | [8] |
Me | eeeeeee | 88 | eeeeeeeeeeeeeeeee (eeeeeeeee eeeee/eeeeeee 8:8) | 88 | – | 88 | [8] |
MM8MM8MM8MM8M(MM8)8 | – | 8 | eeeeeeeeeeeeeeeee (MM8Me8) | 88 | 88–88 | – | [88] |
Meeeeeeeeeee Meeeeeeee
Meeeeeeeee Meee Meeeeeeeee 8; Meeeeee Meeeeeeee:[8]
MMMMMMM: Meeeeee eeeeeeee eeeeee eeeeeeeee eeee eeeee eeeeeeeee eeeee eeeeeee ee eeeeeeeee eeeee. Me ee eeeeeeeee eeeeeeeeeee ee eee eeeeeee.
Me e eeee ee eee eeeeeeeeee eeee 8 (8.8 eee) eee eeeeeeee (8.8 eee) ee Me8M (88 eM) ee −88°M eee eeeee eeeeeeee e eeee ee MMMe8 (8.88 eee) ee Me8M (8 eM). Meeee eee eeeeeeee eee eeeeeeeee (88–88 eee) eee eeeeeeeeeeee eeeeeeeeee eeeeeeee eee eeeeeee ee eeeeeeeeee eee eee eeeeeee eee eeeeeeee eeee eee eeeeeeee.
References
[2] | Meeeee, M. M., Me Mee Meeeeeeee ee Meee Meeeeee, Meeee, M., Me.; Meeee-Meeeeeeeeeee: Mee Meee, (8888), e 88. |
[3] | Meeeeee, M. M.; Meeeeee, M. M.; Meeeee, M.; Mee, M. M.; Meeeeee, M.; Meeeee, M. M.; Meeeeeee, M. M. M.; Meee, M. M.; Meee, M. M., M. Meee. Mee., (8888), 888. |
[4] | Meeeeee, M.; Meeeee, M. M., M. Meee. Mee., (8888), 8888. |
[5] | Meeeeee, M., M. Meee. Mee. M, (8888), 8888. |
[6] | Meeeee, M. M.; Meeeeee, M. M., Mee. Meee. Meeeee. Mee., (8888) 8, 888. |
[10] | Meeee, M.; Meeee, M. M.; Meee, M. M., M. Mee. Meee., (8888) 88, 8888. |
[11] | Meeeeeeeeee, M.; Meeeeee, M., Meee. Mee. (Meeeee), (8888), 8888. |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) M 8-8, 888.
- 8.Meeeee-Meee, (8888) M 8-8, 888.