Science of Synthesis

Zhang, M.; Hanson, P. R., Science of Synthesis, (2007) 20, 912.

The traditional approach to transform a lactone, e.g. ‌197‌ or ‌201‌, into the corresponding hydroxy ester is to react it with an alcohol in the presence of an acid, e.g. sulfuric ­acid[‌259‌–‌261‌] or 4-toluenesulfonic acid (‌Scheme 61‌).[‌262‌–‌264‌] Storage of alcoholic solutions of lactones, e.g. ‌198‌ or ‌200‌, on Amberlyst-15 also results in the formation of the corresponding hydroxy esters, e.g. ‌199‌, in high yields (‌Scheme 61‌).[‌265‌]

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Meeeee 8-Meeeeeeeeeeeeeee (‌888‌, e = 8); Meeeeee Meeeeeeee:[‌888‌]

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References

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• 8.Meeeee-Meee, (8888) 8, 888.