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Zhang, M.; Hanson, P. R., Science of Synthesis, (2007) 20, 912.
The traditional approach to transform a lactone, e.g. 197 or 201, into the corresponding hydroxy ester is to react it with an alcohol in the presence of an acid, e.g. sulfuric acid[259–261] or 4-toluenesulfonic acid (Scheme 61).[262–264] Storage of alcoholic solutions of lactones, e.g. 198 or 200, on Amberlyst-15 also results in the formation of the corresponding hydroxy esters, e.g. 199, in high yields (Scheme 61).[265]
Meeeee 88 Meeeee Meeeeeeeeee ee Meeeeeee[888–888]
Me eeeeeeee, ee eee eeeeeeee ee ee eeeeeee, eeee, eee eeeeeeeeeeee, eeee- eee eee-eeeeeeee-eeee eeeeeeee 888 eee eeeeeee eeeeeeeee eeee eeeeee eeeeee 888 (Meeeee 88).[888] Mee eeeeeeee ee eeeeeee eee eeeeeeee eeeee eeee eeeeeeeeee eeee ee eee eeeeeeee ee ee eeeee eeeee.
Meeeee 88 Mee-Meee Meeeeeeee ee Meeeee Meeeee eeee Meeeeeee[888]
Meeeeeeeeeee Meeeeeeee
Meeeee 8-Meeeeeeeeeeeeeee (888, e = 8); Meeeeee Meeeeeeee:[888]
M eeee ee γ-eeeeeeeeeeeee (888, e = 8; 88.8 eeee) ee eeeee MeMM (88 eM) eee eeeeee ee Meeeeeeee-88 (88 e) eeee eeeeeeeeee eeeeeee eee 88 e. Mee MeMM eee eeeeeeee eee eee Meeeeeeee-88 eee eeeeee eeee eeeeeee MeMM (8 × 88 eM). Mee MeMM eee eeeeeee eeee eee eeeeeeee eeeee eee eee eeeeeee eee eeeeeeeee; eeeee: 88.8 e (88%); ee 888–888°M/8–88 Meee.
References
[259] | Meeeeeeé, M.; Meeee, M.; Meeeeñe, M. M.; Meeeíe Meeee, M. M., Meeeeeeeeee: Meeeeeeee, (8888) 8, 888. |
[260] | Me Meeeeee, M.; Mee, M.; Meeee, M.-M.; Meeee, M.-M.; Meeeee, M., Meeeeeeeeee Meee., (8888) 88, 8888. |
[261] | Meeee, M. M.; Meeeeee, M. M., M. Meee. Mee., Meeeee Meeee. 8, (8888), 8888. |
[262] | Meee, M.-M.; Mee, M.-M.; Mee, M.-e., Meeeeeeeeee: Meeeeeeee, (8888) 8, 8888. |
[263] | Meee, M. M.; Meeeeee, M., Meeeeee, (8888), 8888. |
[264] | Meeeeeee, M. M.; Meeeee, M. M.; Meeeeee, M. M.; Meeeeee, M. M.; Meeeeeee, M. M.; Meee, M., Mee. Meee., (8888) 8, 888. |
[265] | Meeee, M. M.; Meeeeeeeee, M., Meeee. Meeeee., (8888) 88, 8888. |
[266] | Meee, M. M., M. Mee. Meee., (8888) 88, 8888. |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) 8, 888.