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Please login or sign up for a free trial to access the full content. Method 4: Carbonylation Reactions of Formates with Organic Halides

DOI: 10.1055/sos-SD-020-00774

Zhang, M.; Hanson, P. R.Science of Synthesis, (200720917.

Benzyl, aryl, and alkyl halides 213 react with formate esters 214 under carbon monoxide atmosphere in the presence of dichlorobis(hexa-1,5-diene)dirhodium(I), potassium iodide, and, optionally, tetrakis(triphenylphosphine)palladium(0) to give the corresponding esters 215 in 2094% yields (Scheme 69).[‌287‌] Formates are useful alkoxy-transfer agents for a variety of chlorides and bromides by this method.

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