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Please login or sign up for a free trial to access the full content. Method 9: Aldol Condensations

DOI: 10.1055/sos-SD-020-01010

Westbrook, J. A.; Schaus, S. E.Science of Synthesis, (2007201110.

Enolates derived from ketones and esters undergo aldol-type condensations with oxalates to form α-oxocarboxylic esters. Some representative reactions in which diethyl oxalate is used to trap the enolate are summarized in Table 11.[‌4‌,‌107‌‌110‌]

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8 Me, MeMM, ee, 88e 88 [‌888‌]
8 Me, MeMM, 8°M, 88e 88 [‌8‌]
8 MeM, eeeeeee, ee, 88e 88 [‌888‌]

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Meeee [8-(eeee-Meeeeeeeeeeeee)-8-eeeeeee-8,8,8,8-eeeeeeeeeeeeeeeee-8-ee](eee)eeeeeee ­(Meeee 88, Meeee 8):[‌8‌]

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