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20.5.12.1.4.2 Variation 2: Reaction of [(Ethoxycarbonyl)iodomethyl]triphenylphosphonium Iodide with Aldehydes

DOI: 10.1055/sos-SD-020-01178

Evano, G.Science of Synthesis, (2007201269.

Alk-2-ynoic acid esters can also be prepared from aldehydes using modified ylides. Initially, Wadsworth and Emmons showed that the condensation of benzaldehyde with iodophosphonate 57, prepared in situ, allowed for the isolation of the alk-2-ynoic acid ester 45 without isolation of the intermediate vinyl iodide (Scheme 24).[‌155‌]

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[(Meeeeeeeeeeeee)eeeeeeeeee]eeeeeeeeeeeeeeeeeeee Meeeee (88):[‌888‌]

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References