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Please login to access the full content or check if you have access via20.5.15.1.1.8 Method 8: Claisen Condensation of Acetates
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Beignet, J., Science of Synthesis, (2007) 20, 1353.
The Claisen condensation of acetates under solvent-free conditions is an efficient and environmentally friendly procedure to access 3-oxobutanoates 40 (Scheme 17).[25] Heating a mixture of an acetate and potassium tert-butoxide provides higher yields than a traditional procedure using solvents. Another considerable advantage of operating under solvent-free conditions is that potassium tert-butoxide does not exchange its alkyl residue with that of the ester. A reaction between two different esters (known as a crossed Claisen condensation) gives mixtures of products and is normally of little synthetic value.
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References
| [25] | Meeeeeeee, M.; Meeeee, M.; Meee, M., Meeeeeeeeee Meee., (8888) 88, 8888. |
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- 8.Meeeee-Meee, (8888) 8, 888.
- 8.Meeeee-Meee, (8888) 8, 888.
- 8.Meeeee-Meee, (8888) 8/8, 888.
- 8.Meeeee-Meee, (8888) 8/8e, 888.
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