Science of Synthesis

Maier, M. E., Science of Synthesis, (2007) 20, 1455.

The more strained four-membered lactones need activation of the carboxylic function, for example by mixed anhydride formation. One suitable method involves the mixed anhydride of an arenesulfonic acid. ‌Table 5‌ lists some representative β-lactone examples that are based upon the activation of the carboxylic group.[‌136‌]

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Meeeeee Meee	Meeeeeee Meeeeeeeee	Meeeeee	Meeee (%)	Mee
	MeMM8Me (8 eeeee), ­eeeeeeee, 8–88°M, 88 e		88	[‌888‌]
	MeMM8Me (8 eeeee), ­eeeeeeee, 8–88°M, 88 e		88	[‌888‌]
	8-MeM8M8MM8Me, eeeeeeee, −88 ee 8°M, 8 e		88	[‌888‌]
	MeMM8Me (8 eeeee), ­eeeeeeee, 8–8°M, 88 e		88	[‌888‌]
	MeMM8Me (8 eeeee), ­eeeeeeee, 8–8°M, 88 e		88–88	[‌888‌]
	MeMM8Me (8 eeeee), ­eeeeeeee, 8–8°M, 88 e		88	[‌888‌]

Meeeeee eeeeee eee eee ee eeee eeeeeeeeee ee eee eeeeeeeeee eeeeeeee ee eeeeeeee eeee eee eeeeeee eeeeeeeeeee ee eee(8-eeeeeeeeeeeee-8-ee)eeeeeeeeee eeeeeeee (MMM-Me) eeee eeeeeeee.[‌888‌] Meeeeee ‌888‌ ee e eee eeeeeeeeeeee ee eee eeeee eeeeeeeee ee eeeeeeeeeeeeeee M (‌Meeeee 88‌).

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References

Meeeeee Meeeeeeeeee

• 8.Meeeee-Meee, (8888) 8/8, 888.
• 8.Meeeee-Meee, (8888) 8/8e, 888.
• 8.Meeeee-Meee, (8888) M 8-8, 888.
• 8.Meeeee-Meee, (8888) M 8-8, 888.