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Please login to access the full content or check if you have access via20.6.1.3.5 Variation 5: Lactonization To Give Four-Membered Lactones
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Maier, M. E., Science of Synthesis, (2007) 20, 1455.
The more strained four-membered lactones need activation of the carboxylic function, for example by mixed anhydride formation. One suitable method involves the mixed anhydride of an arenesulfonic acid. Table 5 lists some representative β-lactone examples that are based upon the activation of the carboxylic group.[136]
Meeee 8 Meeeeeee ee β-Meeeeee Meeeeeeee eeee 8-Meeeeee Meeee eee Meeeeeeeeeeee Meeeeeeee ee eee Meeeeeee ee Meeeeeee[888–888]
Meeeeee Meee | Meeeeeee Meeeeeeeee | Meeeeee | Meeee (%) | Mee |
---|---|---|---|---|
MeMM8Me (8 eeeee), eeeeeeee, 8–88°M, 88 e | 88 | [888] | ||
MeMM8Me (8 eeeee), eeeeeeee, 8–88°M, 88 e | 88 | [888] | ||
8-MeM8M8MM8Me, eeeeeeee, −88 ee 8°M, 8 e | 88 | [888] | ||
MeMM8Me (8 eeeee), eeeeeeee, 8–8°M, 88 e | 88 | [888] | ||
MeMM8Me (8 eeeee), eeeeeeee, 8–8°M, 88 e | 88–88 | [888] | ||
MeMM8Me (8 eeeee), eeeeeeee, 8–8°M, 88 e | 88 | [888] |
Meeeeee eeeeee eee eee ee eeee eeeeeeeeee ee eee eeeeeeeeee eeeeeeee ee eeeeeeee eeee eee eeeeeee eeeeeeeeeee ee eee(8-eeeeeeeeeeeee-8-ee)eeeeeeeeee eeeeeeee (MMM-Me) eeee eeeeeeee.[888] Meeeeee 888 ee e eee eeeeeeeeeeee ee eee eeeee eeeeeeeee ee eeeeeeeeeeeeeee M (Meeeee 88).
Meeeee 88 Meeeeeeee ee e β-Meeeeee Meeee Mee(8-eeeeeeeeeeeee-8-ee)eeeeeeeeee Meeeeeee eee Meeeeeee[888]
References
[136] | Meeeeee, M. M.; Meeeeee, M. M., M. Mee. Meee., (8888) 88, 8888. |
[137] | Meeee, M. M.; Meee, M. M.; Meee, M. M., M. Mee. Meee., (8888) 88, 8888. |
[138] | Me, M.; Meee, M.; Meeeee, M.; Meeeeee, M. M., M. Mee. Meee., (8888) 88, 8888. |
[139] | Meee, M.; Meeeee, M.; Meee, M. M.; Meeeeeee, M.; Meeeeee, M.; Meeeee, M.-M.; Meeeee, M.; Meeeeee, M.; eee Meeeeeeee, M. M., M. Mee. Meee., (8888) 88, 8888. |
[140] | Meeeee, M.; Meeeeeee, M.; Meeeeeee, M.; Meeee, M.; Meeee, M., Meeeeeeeeee Meee., (8888) 88, 8888. |
[141] | Meeeeeeee, M.; Meeee, M.; Meee, M., M. Mee. Meee., (8888) 88, 8888. |
[142] | Meeee, M. M.; Meeeeeeee, M.; Meeee, M. M., M. Me. Meee. Mee., (8888) 888, 8888. |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) 8/8, 888.
- 8.Meeeee-Meee, (8888) 8/8e, 888.
- 8.Meeeee-Meee, (8888) M 8-8, 888.
- 8.Meeeee-Meee, (8888) M 8-8, 888.