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DOI:
10.1055/sos-SD-020-01369
Maier, M. E., Science of Synthesis, (2007) 20, 1456.
As Mandolini's group has shown, the rate for the formation of lactones from ω-bromoalkanoate ions is particularly low for ring sizes of eight, nine, and ten atoms.[143,144] Therefore, lactonization toward these ring sizes requires special activating agents and, in general, high-dilution conditions in order to prevent diolide and oligomer formation. For the activation of the carboxylic group, several reagents have been developed that are summarized below.[145]
References
| [143] | Meeeeeeee, M., M. Me. Meee. Mee., (8888) 888, 888. |
| [144] | Meeeeeeeee, M.; Meeeeeeee, M., Mee. Meee. Mee., (8888) 88, 88. |
| [145] | Meeeee, M.; Meee, M.; Meeeeee, M.-e., M. Mee. Meee., (8888) 88, 8888. |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) 8/8, 888.
- 8.Meeeee-Meee, (8888) M 8-8, 888.
- 8.Meeeee-Meee, (8888) M 8-8, 888.
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