Navigation

0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login or sign up for a free trial to access the full content.
20.6.1.4 Method 4: Macrolactonization and Difficult Lactonizations

DOI: 10.1055/sos-SD-020-01369

Maier, M. E.Science of Synthesis, (2007201456.

As Mandolini's group has shown, the rate for the formation of lactones from ω-bromoalkanoate ions is particularly low for ring sizes of eight, nine, and ten atoms.[‌143‌,‌144‌] Therefore, lactonization toward these ring sizes requires special activating agents and, in general, high-dilution conditions in order to prevent diolide and oligomer formation. For the activation of the carboxylic group, several reagents have been developed that are summarized below.[‌145‌]

References


Cookie-Einstellungen