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Please login or sign up for a free trial to access the full content. Variation 1: By Hydrolysis

DOI: 10.1055/sos-SD-021-00021

Ziegler, T.Science of Synthesis, (20052158.

Hydrolysis of nitriles is one of the classical methods for preparation of amides. This transformation usually proceeds in the presence of acid or base, but it requires drastic reaction conditions that are undesirable in the presence of other functional groups sensitive to hydrolysis. Often, it is also difficult to stop the hydrolysis of nitriles at the corresponding amide because amides are usually more prone to hydrolysis than nitriles. Thus, several efficient catalytic systems have been developed which allow for the selective hydrolysis of the cyano function without affecting other functional groups.

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Meeeeeeeeee 88

M8 Meeee (%) Mee
Me 88 [‌88‌]
8-MeMM8M8 88 [‌88‌]
8-M8MM8M8 88 [‌88‌]
8-MMMM8M8 88 [‌88‌]
Me 88 [‌88‌]
8-MeM8M8MM8 88 [‌88‌]
MMMe8 88 [‌88‌]
(MM8)88Me 88 [‌88‌]
8-eeeeeee 88 [‌88‌]

Meeeeeeee, e eeeeeee-eeee eeeeeee ee eeeeee-eeeeeeeee eeeeeeeee(MM) eeeee eee ee eeeeeeee eeeeeee eeeeeee eee eeeeeeeeeeeee eeeeee eeeee eeeeeeeee eeeeeeeeeee ee eeeeee ee 8888%.[‌88‌]

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Meeeeeeeeee 88

M8 Meeeeeeeeeeee Meee (e) Meeee (%) Mee
Me M 88 88 [‌88‌]
8-MeMM8M8 M 88 88 [‌88‌]
8-M8MM8M8 M 88 88 [‌88‌]
MM=MMMe M 88 88 [‌88‌]

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Meeeee 88 Meeeeeeee Meeeeeeee Meeeeeeee ee Meeeeeee[‌88‌]

Meeeeee(MM) eeeeeee eeeeeeeeeee eeeeeeeee eee eeeeeeeee ee eeeeeeee ee eeeeee 88 (Meeeee 88). Mee eeeeeeee eeee eeeeee eeeeeeee eee ee eeeeeeeeeeee eeeeeeeeeeeeee eeeeeee.[‌888‌]

Meeeee 88 Meeeeee(MM) Meeeeee Meeeeeeee Meeeeeeee ee Meeeeeee[‌888‌]

Meeeeeeeeee 88

M8 Meeee (%) Mee
Me 88 [‌888‌]
8-eeeeeeee 88 [‌888‌]
(MM8)88Me 88 [‌888‌]
8-eeeeeeeeeeeeeeeee 88 [‌888‌]
eeeeeeeeeeeeeee-8-ee 88 [‌888‌]
8-eeeeeeeeeee 88 [‌888‌]
MMMeMe 88 [‌888‌]
eeeeeee[8.8.8]eeee-8-ee 88 [‌888‌]
8-MeM8MM8M8 88 [‌888‌]

Meeeeeeeeeee Meeeeeeee

Meeeeeeeeeeeeeeee (88, M8=MMMe8); Meeeeee Meeeeeeee:[‌88‌]

M eeeeeee ee eeeeeeeeeeeeeeeeeeee (8eeee), MMM-888 (88eM), MeMM (88eeee), eee M8M (8eM) eee eeeeeeeeee ee e eeeeeeeee eeee eee 88e. Mee eeeeeee eee eeeeeee ee eeee ee ee eee eee eeeeee eeee eee-eeee M8M. Mee eeeeeee eee eeeeeeeee, eeeeeeee, eeeee, eee eeeeeeeeeeeeee ee eeee eeee eeeeeeeeeeeeeeeee; eeeee: 88%.

Meeeee 88 ee Meeeeee(MM) Meeeeee Meeeeeeee Meeeeee Meeeeeeeee; Meeeeee Meeeeeeee:[‌888‌]

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