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21.1.2.9.1 Variation 1: By Hydrolysis

DOI: 10.1055/sos-SD-021-00021

Ziegler, T.Science of Synthesis, (20052158.

Hydrolysis of nitriles is one of the classical methods for preparation of amides. This transformation usually proceeds in the presence of acid or base, but it requires drastic reaction conditions that are undesirable in the presence of other functional groups sensitive to hydrolysis. Often, it is also difficult to stop the hydrolysis of nitriles at the corresponding amide because amides are usually more prone to hydrolysis than nitriles. Thus, several efficient catalytic systems have been developed which allow for the selective hydrolysis of the cyano function without affecting other functional groups.

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References


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