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21.1.2.9.2 Variation 2: N-Alkylation by Ritter-Type Reactions

DOI: 10.1055/sos-SD-021-00021

Ziegler, T.Science of Synthesis, (20052161.

Montmorillonite KSF clay under microwave irradiation catalyzes the Ritter reaction of a wide variety of primary, secondary, and tertiary alcohols with nitriles to afford the corresponding amides 17 in 75% yield (Scheme 29).[‌96‌] Similarly, Nafion-H resin can be used for the same purpose.[‌97‌]

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Meeeee 88 ee Meeeee Meeeeeee ee Meeeeeee eeee Meeeeeee Meeeeeeee ee Meeeeeeeeeeeeee MMM Meee eeeee Meeeeeeee Meeeeeeeeee; Meeeeee Meeeeeeee:[‌88‌]

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8-Meeeeee-M-eeee-eeeeeeeeeeeeee (88, M8=8-MMe); Meeeeee Meeeeeeee:[‌88‌]

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References