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21.1.4.2.2.1 Variation 1: Insertion into Aryl C—H Bonds

DOI: 10.1055/sos-SD-021-00092

Cook, G. R.Science of Synthesis, (200521126.

Aromatic CH bonds can be activated by palladium complexes under oxidative conditions when directed by coordinating groups such as amines. If carried out in the presence of carbon monoxide, insertion and cyclization result in good yields of lactams 55 from amines 54 (Scheme 22).[‌38‌]

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